About Acyl-protein thioesterase 1
Acyl-protein thioesterase 1 (LYPLA1) is a protein
from Homo sapiens identified by UniProt accession
O75608, 230 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Acyl-protein thioesterase 1 |
|---|
| UniProt accession | O75608 |
|---|
| Gene | LYPLA1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 230 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (69)
Diseases linked to this target (Open Targets).
- viral load · score 0.11
- melanoma · score 0.09
- drug use measurement · score 0.08
- neoplasm · score 0.07
- Familial exudative vitreoretinopathy · score 0.05
- X-linked retinal dysplasia · score 0.05
- severe early-childhood-onset retinal dystrophy · score 0.05
- X-linked retinoschisis · score 0.04
- Huntington disease · score 0.04
- platelet component distribution width · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75608-F1 | alphafold | PREDICTED | 95.50 | — |
Amino-acid sequence (230 residues)
MCGNNMSTPL PAIVPAARKA TAAVIFLHGL GDTGHGWAEA FAGIRSSHIK YICPHAPVRP VTLNMNVAMP SWFDIIGLSP DSQEDESGIK QAAENIKALI DQEVKNGIPS NRIILGGFSQ GGALSLYTAL TTQQKLAGVT ALSCWLPLRA SFPQGPIGGA NRDISILQCH GDCDPLVPLM FGSLTVEKLK TLVNPANVTF KTYEGMMHSS CQQEMMDVKQ FIDKLLPPID
Explore Acyl-protein thioesterase 1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets