Serine/threonine-protein kinase 16 (STK16)

About Serine/threonine-protein kinase 16

Serine/threonine-protein kinase 16 (STK16) is a protein from Homo sapiens identified by UniProt accession O75716, 305 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	Serine/threonine-protein kinase 16
UniProt accession	O75716
Gene	STK16
Organism	Homo sapiens
Length	305 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (15)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (48)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.47
reticulocyte count · score 0.18
reticulocyte measurement · score 0.16
date of birth · score 0.12
cancer · score 0.08
triglyceride measurement · score 0.08
lung adenocarcinoma · score 0.07
hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.06
platelet component distribution width · score 0.06
Red cell distribution width · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75716-F1	alphafold	PREDICTED	93.08	—

Amino-acid sequence (305 residues)

MGHALCVCSR GTVIIDNKRY LFIQKLGEGG FSYVDLVEGL HDGHFYALKR ILCHEQQDRE EAQREADMHR LFNHPNILRL VAYCLRERGA KHEAWLLLPF FKRGTLWNEI ERLKDKGNFL TEDQILWLLL GICRGLEAIH AKGYAHRDLK PTNILLGDEG QPVLMDLGSM NQACIHVEGS RQALTLQDWA AQRCTISYRA PELFSVQSHC VIDERTDVWS LGCVLYAMMF GEGPYDMVFQ KGDSVALAVQ NQLSIPQSPR HSSALRQLLN SMMTVDPHQR PHIPLLLSQL EALQPPAPGQ HTTQI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards