About Solute carrier family 22 member 3
Solute carrier family 22 member 3 (SLC22A3) is a protein
from Homo sapiens identified by UniProt accession
O75751, 556 residues long.
MolForge cross-references it against 0 known binders and
185 disease associations.
Target properties
| Protein name | Solute carrier family 22 member 3 |
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| UniProt accession | O75751 |
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| Gene | SLC22A3 |
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| Organism | Homo sapiens |
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| Length | 556 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (9)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (185)
Diseases linked to this target (Open Targets).
- lipoprotein A measurement · score 0.61
- low density lipoprotein cholesterol measurement · score 0.51
- prostate carcinoma · score 0.49
- type 2 diabetes mellitus · score 0.47
- neurodegenerative disease · score 0.47
- sex hormone-binding globulin measurement · score 0.46
- body mass index · score 0.46
- BMI-adjusted waist-hip ratio · score 0.45
- lean body mass · score 0.45
- monocyte count · score 0.45
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75751-F1 | alphafold | PREDICTED | 83.48 | — |
Amino-acid sequence (556 residues)
MPSFDEALQR VGEFGRFQRR VFLLLCLTGV TFAFLFVGVV FLGTQPDHYW CRGPSAAALA ERCGWSPEEE WNRTAPASRG PEPPERRGRC QRYLLEAAND SASATSALSC ADPLAAFPNR SAPLVPCRGG WRYAQAHSTI VSEFDLVCVN AWMLDLTQAI LNLGFLTGAF TLGYAADRYG RIVIYLLSCL GVGVTGVVVA FAPNFPVFVI FRFLQGVFGK GTWMTCYVIV TEIVGSKQRR IVGIVIQMFF TLGIIILPGI AYFIPNWQGI QLAITLPSFL FLLYYWVVPE SPRWLITRKK GDKALQILRR IAKCNGKYLS SNYSEITVTD EEVSNPSFLD LVRTPQMRKC TLILMFAWFT SAVVYQGLVM RLGIIGGNLY IDFFISGVVE LPGALLILLT IERLGRRLPF AASNIVAGVA CLVTAFLPEG IAWLRTTVAT LGRLGITMAF EIVYLVNSEL YPTTLRNFGV SLCSGLCDFG GIIAPFLLFR LAAVWLELPL IIFGILASIC GGLVMLLPET KGIALPETVD DVEKLGSPHS CKCGRNKKTP VSRSHL
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