About Signal transducing adapter molecule 2
Signal transducing adapter molecule 2 (STAM2) is a protein
from Homo sapiens identified by UniProt accession
O75886, 525 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | Signal transducing adapter molecule 2 |
|---|
| UniProt accession | O75886 |
|---|
| Gene | STAM2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 525 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (28)
Diseases linked to this target (Open Targets).
- listeriosis · score 0.37
- smoking status measurement · score 0.29
- glioblastoma multiforme · score 0.28
- pulse pressure measurement · score 0.26
- breast adenocarcinoma · score 0.26
- lung adenocarcinoma · score 0.25
- thyroid gland adenocarcinoma · score 0.25
- chemotherapy-induced alopecia · score 0.25
- ovarian cancer · score 0.23
- endometrial cancer · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75886-F1 | alphafold | PREDICTED | 68.64 | — |
Amino-acid sequence (525 residues)
MPLFTANPFE QDVEKATNEY NTTEDWSLIM DICDKVGSTP NGAKDCLKAI MKRVNHKVPH VALQALTLLG ACVANCGKIF HLEVCSRDFA TEVRAVIKNK AHPKVCEKLK SLMVEWSEEF QKDPQFSLIS ATIKSMKEEG ITFPPAGSQT VSAAAKNGTS SNKNKEDEDI AKAIELSLQE QKQQHTETKS LYPSSEIQLN NKVARKVRAL YDFEAVEDNE LTFKHGEIII VLDDSDANWW KGENHRGIGL FPSNFVTTNL NIETEAAAVD KLNVIDDDVE EIKKSEPEPV YIDEDKMDRA LQVLQSIDPT DSKPDSQDLL DLEDICQQMG PMIDEKLEEI DRKHSELSEL NVKVLEALEL YNKLVNEAPV YSVYSKLHPP AHYPPASSGV PMQTYPVQSH GGNYMGQSIH QVTVAQSYSL GPDQIGPLRS LPPNVNSSVT AQPAQTSYLS TGQDTVSNPT YMNQNSNLQS ATGTTAYTQQ MGMSVDMSSY QNTTSNLPQL AGFPVTVPAH PVAQQHTNYH QQPLL
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