About Delta(14)-sterol reductase TM7SF2
Delta(14)-sterol reductase TM7SF2 (TM7SF2) is a protein
from Homo sapiens identified by UniProt accession
O76062, 418 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Delta(14)-sterol reductase TM7SF2 |
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| UniProt accession | O76062 |
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| Gene | TM7SF2 |
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| Organism | Homo sapiens |
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| Length | 418 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- chronic myeloproliferative disorder · score 0.04
- linear and whorled nevoid hypermelanosis · score 0.03
- 22q11.2 deletion syndrome · score 0.03
- neutropenia, severe congenital, 1, autosomal dominant · score 0.03
- visual perception measurement · score 0.03
- eosinophil peroxidase deficiency · score 0.03
- neoplasm · score 0.03
- appendicular lean mass · score 0.02
- kidney failure · score 0.02
- Acute kidney injury · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O76062-F1 | alphafold | PREDICTED | 93.84 | — |
Amino-acid sequence (418 residues)
MAPTQGPRAP LEFGGPLGAA ALLLLLPATM FHLLLAARSG PARLLGPPAS LPGLEVLWSP RALLLWLAWL GLQAALYLLP ARKVAEGQEL KDKSRLRYPI NGFQALVLTA LLVGLGMSAG LPLGALPEML LPLAFVATLT AFIFSLFLYM KAQVAPVSAL APGGNSGNPI YDFFLGRELN PRICFFDFKY FCELRPGLIG WVLINLALLM KEAELRGSPS LAMWLVNGFQ LLYVGDALWH EEAVLTTMDI THDGFGFMLA FGDMAWVPFT YSLQAQFLLH HPQPLGLPMA SVICLINATG YYIFRGANSQ KNTFRKNPSD PRVAGLETIS TATGRKLLVS GWWGMVRHPN YLGDLIMALA WSLPCGVSHL LPYFYLLYFT ALLVHREARD ERQCLQKYGL AWQEYCRRVP YRIMPYIY
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