About Signal recognition particle subunit SRP72
Signal recognition particle subunit SRP72 (SRP72) is a protein
from Homo sapiens identified by UniProt accession
O76094, 671 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Signal recognition particle subunit SRP72 |
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| UniProt accession | O76094 |
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| Gene | SRP72 |
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| Organism | Homo sapiens |
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| Length | 671 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (50)
Diseases linked to this target (Open Targets).
- autosomal dominant aplasia and myelodysplasia · score 0.63
- neurodegenerative disease · score 0.42
- endometrial cancer · score 0.11
- attention deficit hyperactivity disorder · score 0.04
- schizophrenia 15 · score 0.04
- cancer · score 0.02
- metabolite measurement · score 0.02
- response to selective serotonin reuptake inhibitor · score 0.02
- high density lipoprotein cholesterol measurement · score 0.02
- adolescent idiopathic scoliosis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O76094-F1 | alphafold | PREDICTED | 81.75 | — |
Amino-acid sequence (671 residues)
MASGGSGGVS VPALWSEVNR YGQNGDFTRA LKTVNKILQI NKDDVTALHC KVVCLIQNGS FKEALNVINT HTKVLANNSL SFEKAYCEYR LNRIENALKT IESANQQTDK LKELYGQVLY RLERYDECLA VYRDLVRNSQ DDYDEERKTN LSAVVAAQSN WEKVVPENLG LQEGTHELCY NTACALIGQG QLNQAMKILQ KAEDLCRRSL SEDTDGTEED PQAELAIIHG QMAYILQLQG RTEEALQLYN QIIKLKPTDV GLLAVIANNI ITINKDQNVF DSKKKVKLTN AEGVEFKLSK KQLQAIEFNK ALLAMYTNQA EQCRKISASL QSQSPEHLLP VLIQAAQLCR EKQHTKAIEL LQEFSDQHPE NAAEIKLTMA QLKISQGNIS KACLILRSIE ELKHKPGMVS ALVTMYSHEE DIDSAIEVFT QAIQWYQNHQ PKSPAHLSLI REAANFKLKY GRKKEAISDL QQLWKQNPKD IHTLAQLISA YSLVDPEKAK ALSKHLPSSD SMSLKVDVEA LENSAGATYI RKKGGKVTGD SQPKEQGQGD LKKKKKKKKG KLPKNYDPKV TPDPERWLPM RERSYYRGRK KGKKKDQIGK GTQGATAGAS SELDASKTVS SPPTSPRPGS AATVSASTSN IIPPRHQKPA GAPATKKKQQ QKKKKGGKGG W
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