About E3 ubiquitin-protein ligase listerin
E3 ubiquitin-protein ligase listerin (LTN1) is a protein
from Homo sapiens identified by UniProt accession
O94822, 1766 residues long.
MolForge cross-references it against 0 known binders and
116 disease associations.
Target properties
| Protein name | E3 ubiquitin-protein ligase listerin |
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| UniProt accession | O94822 |
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| Gene | LTN1 |
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| Organism | Homo sapiens |
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| Length | 1766 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (116)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.43
- reticulocyte measurement · score 0.36
- Immature Reticulocyte Fraction Measurement · score 0.34
- serum gamma-glutamyl transferase measurement · score 0.25
- serum alanine aminotransferase measurement · score 0.25
- clear cell renal carcinoma · score 0.18
- aspartate aminotransferase to alanine aminotransferase ratio · score 0.15
- body mass index · score 0.13
- Neurodevelopmental disorder · score 0.12
- body weight · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94822-F1 | alphafold | PREDICTED | 80.47 | — |
Amino-acid sequence (1766 residues)
MGGKNKQRTK GNLRPSNSGR AAELLAKEQG TVPGFIGFGT SQSDLGYVPA IQGAEEIDSL VDSDFRMVLR KLSKKDVTTK LKAMQEFGTM CTERDTETVK GVLPYWPRIF CKISLDHDRR VREATQQAFE KLILKVKKQL APYLKSLMGY WLMAQCDTYT PAAFAAKDAF EAAFPPSKQP EAIAFCKDEI TSVLQDHLIK ETPDTLSDPQ TVPEEEREAK FYRVVTCSLL ALKRLLCLLP DNELDSLEEK FKSLLSQNKF WKYGKHSVPQ IRSAYFELVS ALCQRIPQLM KEEASKVSPS VLLSIDDSDP IVCPALWEAV LYTLTTIEDC WLHVNAKKSV FPKLSTVIRE GGRGLATVIY PYLLPFISKL PQSITNPKLD FFKNFLTSLV AGLSTERTKT SSLESSAVIS AFFECLRFIM QQNLGEEEIE QMLVNDQLIP FIDAVLKDPG LQHGQLFNHL AETLSSWEAK ADTEKDEKTA HNLENVLIHF WERLSEICVA KISEPEADVE SVLGVSNLLQ VLQKPKSSLK SSKKKNGKVR FADEILESNK ENEKCVSSEG EKIEGWELTT EPSLTHNSSG LLSPLRKKPL EDLVCKLADI SINYVNERKS EQHLRFLSTL LDSFSSSRVF KMLLGDEKQS IVQAKPLEIA KLVQKNPAVQ FLYQKLIGWL NEDQRKDFGF LVDILYSALR CCDNDMERKK VLDDLTKVDL KWNSLLKIIE KACPSSDKHA LVTPWLKGDI LGEKLVNLAD CLCNEDLESR VSSESHFSER WTLLSLVLSQ HVKNDYLIGD VYVERIIVRL HETLFKTKKL SEAESSDSSV SFICDVAYNY FSSAKGCLLM PSSEDLLLTL FQLCAQSKEK THLPDFLICK LKNTWLSGVN LLVHQTDSSY KESTFLHLSA LWLKNQVQAS SLDINSLQVL LSAVDDLLNT LLESEDSYLM GVYIGSVMPN DSEWEKMRQS LPMQWLHRPL LEGRLSLNYE CFKTDFKEQD IKTLPSHLCT SALLSKMVLI ALRKETVLEN NELEKIIAEL LYSLQWCEEL DNPPIFLIGF CEILQKMNIT YDNLRVLGNT SGLLQLLFNR SREHGTLWSL IIAKLILSRS ISSDEVKPHY KRKESFFPLT EGNLHTIQSL CPFLSKEEKK EFSAQCIPAL LGWTKKDLCS TNGGFGHLAI FNSCLQTKSI DDGELLHGIL KIIISWKKEH EDIFLFSCNL SEASPEVLGV NIEIIRFLSL FLKYCSSPLA ESEWDFIMCS MLAWLETTSE NQALYSIPLV QLFACVSCDL ACDLSAFFDS TTLDTIGNLP VNLISEWKEF FSQGIHSLLL PILVTVTGEN KDVSETSFQN AMLKPMCETL TYISKEQLLS HKLPARLVAD QKTNLPEYLQ TLLNTLAPLL LFRARPVQIA VYHMLYKLMP ELPQYDQDNL KSYGDEEEEP ALSPPAALMS LLSIQEDLLE NVLGCIPVGQ IVTIKPLSED FCYVLGYLLT WKLILTFFKA ASSQLRALYS MYLRKTKSLN KLLYHLFRLM PENPTYAETA VEVPNKDPKT FFTEELQLSI RETTMLPYHI PHLACSVYHM TLKDLPAMVR LWWNSSEKRV FNIVDRFTSK YVSSVLSFQE ISSVQTSTQL FNGMTVKARA TTREVMATYT IEDIVIELII QLPSNYPLGS IIVESGKRVG VAVQQWRNWM LQLSTYLTHQ NGSIMEGLAL WKNNVDKRFE GVEDCMICFS VIHGFNYSLP KKACRTCKKK FHSACLYKWF TSSNKSTCPL CRETFF
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