About Mitochondrial import receptor subunit TOM70
Mitochondrial import receptor subunit TOM70 (TOMM70) is a protein
from Homo sapiens identified by UniProt accession
O94826, 608 residues long.
MolForge cross-references it against 0 known binders and
41 disease associations.
Target properties
| Protein name | Mitochondrial import receptor subunit TOM70 |
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| UniProt accession | O94826 |
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| Gene | TOMM70 |
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| Organism | Homo sapiens |
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| Length | 608 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (41)
Diseases linked to this target (Open Targets).
- severe acute respiratory syndrome · score 0.46
- COVID-19 · score 0.37
- Global developmental delay · score 0.23
- Abnormal cerebral white matter morphology · score 0.23
- genetic disorder · score 0.18
- diabetic cardiomyopathy · score 0.01
- schizophrenia · score 0.01
- cardiac hypertrophy · score 0.01
- myocardial infarction · score 0.01
- ulnar-mammary syndrome · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94826-F1 | alphafold | PREDICTED | 80.06 | — |
Amino-acid sequence (608 residues)
MAASKPVEAA VVAAAVPSSG SGVGGGGTAG PGTGGLPRWQ LALAVGAPLL LGAGAIYLWS RQQRRREARG RGDASGLKRN SERKTPEGRA SPAPGSGHPE GPGAHLDMNS LDRAQAAKNK GNKYFKAGKY EQAIQCYTEA ISLCPTEKNV DLSTFYQNRA AAFEQLQKWK EVAQDCTKAV ELNPKYVKAL FRRAKAHEKL DNKKECLEDV TAVCILEGFQ NQQSMLLADK VLKLLGKEKA KEKYKNREPL MPSPQFIKSY FSSFTDDIIS QPMLKGEKSD EDKDKEGEAL EVKENSGYLK AKQYMEEENY DKIISECSKE IDAEGKYMAE ALLLRATFYL LIGNANAAKP DLDKVISLKE ANVKLRANAL IKRGSMYMQQ QQPLLSTQDF NMAADIDPQN ADVYHHRGQL KILLDQVEEA VADFDECIRL RPESALAQAQ KCFALYRQAY TGNNSSQIQA AMKGFEEVIK KFPRCAEGYA LYAQALTDQQ QFGKADEMYD KCIDLEPDNA TTYVHKGLLQ LQWKQDLDRG LELISKAIEI DNKCDFAYET MGTIEVQRGN MEKAIDMFNK AINLAKSEME MAHLYSLCDA AHAQTEVAKK YGLKPPTL
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