About [F-actin]-monooxygenase MICAL2
[F-actin]-monooxygenase MICAL2 (MICAL2) is a protein
from Homo sapiens identified by UniProt accession
O94851, 1957 residues long.
MolForge cross-references it against 0 known binders and
104 disease associations.
Target properties
| Protein name | [F-actin]-monooxygenase MICAL2 |
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| UniProt accession | O94851 |
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| Gene | MICAL2 |
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| Organism | Homo sapiens |
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| Length | 1957 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (104)
Diseases linked to this target (Open Targets).
- neuroticism measurement · score 0.46
- leukocyte count · score 0.42
- neutrophil count · score 0.40
- reticulocyte measurement · score 0.39
- PHF-tau measurement · score 0.39
- myeloid white cell count · score 0.38
- lymphocyte count · score 0.38
- reticulocyte count · score 0.36
- neurodegenerative disease · score 0.33
- cortical surface area measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94851-F1 | alphafold | PREDICTED | 56.29 | — |
Amino-acid sequence (1957 residues)
MGENEDEKQA QAGQVFENFV QASTCKGTLQ AFNILTRHLD LDPLDHRNFY SKLKSKVTTW KAKALWYKLD KRGSHKEYKR GKSCTNTKCL IVGGGPCGLR TAIELAYLGA KVVVVEKRDS FSRNNVLHLW PFTIHDLRGL GAKKFYGKFC AGSIDHISIR QLQLILFKVA LMLGVEIHVN VEFVKVLEPP EDQENQKIGW RAEFLPTDHS LSEFEFDVII GADGRRNTLE GFRRKEFRGK LAIAITANFI NRNSTAEAKV EEISGVAFIF NQKFFQDLKE ETGIDLENIV YYKDCTHYFV MTAKKQSLLD KGVIINDYID TEMLLCAENV NQDNLLSYAR EAADFATNYQ LPSLDFAMNH YGQPDVAMFD FTCMYASENA ALVRERQAHQ LLVALVGDSL LEPFWPMGTG CARGFLAAFD TAWMVKSWNQ GTPPLELLAE RESLYRLLPQ TTPENINKNF EQYTLDPGTR YPNLNSHCVR PHQVKHLYIT KELEHYPLER LGSVRRSVNL SRKESDIRPS KLLTWCQQQT EGYQHVNVTD LTTSWRSGLA LCAIIHRFRP ELINFDSLNE DDAVENNQLA FDVAEREFGI PPVTTGKEMA SAQEPDKLSM VMYLSKFYEL FRGTPLRPVD SWRKNYGENA DLSLAKSSIS NNYLNLTFPR KRTPRVDGQT GENDMNKRRR KGFTNLDEPS NFSSRSLGSN QECGSSKEGG NQNKVKSMAN QLLAKFEEST RNPSLMKQER RVSGIGKPVL CSSSGPPVHS CCPKPEEATP SPSPPLKRQF PSVVVTGHVL RELKQVSAGS ECLSRPWRAR AKSDLQLGGT ENFATLPSTR PRAQALSGVL WRLQQVEEKI LQKRAQNLAN REFHTKNIKE KAAHLASMFG HGDFPQNKLL SKGLSHTHPP SPPSRLPSPD PAASSSPSTV DSASPARKEK KSPSGFHFHP SHLRTVHPQL TVGKVSSGIG AAAEVLVNLY MNDHRPKAQA TSPDLESMRK SFPLNLGGSD TCYFCKKRVY VMERLSAEGH FFHRECFRCS ICATTLRLAA YTFDCDEGKF YCKPHFIHCK TNSKQRKRRA ELKQQREEEA TWQEQEAPRR DTPTESSCAV AAIGTLEGSP PDEPTSPKRP KSISEPQHSD AEGDAASPLP SEWTSVRISP GEEAAGQDVL AVRVLVTSED SSSDTESDYG GSEGSHTEPC EEKPWRPGSP HLPHTSLGEA LSRAVSPQCP EEPRAVHAAL QRANSFQSPT PSKYQNWRRE FWWSLTPVNK RTMSPPKDPS PSLPLPSSSS HSSSPPSSSS TSVSGNAPDG SSPPQMTASE PLSQVSRGHP SPPTPNFRRR AVAQGAPREI PLYLPHHPKP EWAEYCLVSP GEDGLSDPAE MTSDECQPAE APLGDIGSNH RDPHPIWGKD RSWTGQELSP LAGEDREKGS TGARKEEEGG PVLVKEKLGL KKLVLTQEQK TMLLDWNDSI PESVHLKAGE RISQKSAENG RGGRVLKPVR PLLLPRAAGE PLPTQRGAQE KMGTPAEQAQ GERNVPPPKS PLRLIANAIR RSLEPLLSNS EGGKKAWAKQ ESKTLPAQAC TRSFSLRKTN SNKDGDQHSP GRNQSSAFSP PDPALRTHSL PNRPSKVFPA LRSPPCSKIE DVPTLLEKVS LQENFPDASK PPKKRISLFS SLRLKDKSFE SFLQESRQRK DIRDLFGSPK RKVLPEDSAQ ALEKLLQPFK STSLRQAAPP PPPPPPPPPP PPTAGGADSK NFPLRAQVTE ASSSASSTSS SSADEEFDPQ LSLQLKEKKT LRRRKKLEKA MKQLVKQEEL KRLYKAQAIQ RQLEEVEERQ RASEIQGVRL EKALRGEADS GTQDEAQLLQ EWFKLVLEKN KLMRYESELL IMAQELELED HQSRLEQKLR EKMLKEESQK DEKDLNEEQE VFTELMQVIE QRDKLVDSLE EQRIREKAED QHFESFVFSR GCQLSRT
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