About Transmembrane and coiled-coil domains protein 1
Transmembrane and coiled-coil domains protein 1 (TMCC1) is a protein
from Homo sapiens identified by UniProt accession
O94876, 653 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | Transmembrane and coiled-coil domains protein 1 |
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| UniProt accession | O94876 |
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| Gene | TMCC1 |
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| Organism | Homo sapiens |
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| Length | 653 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- BMI-adjusted waist-hip ratio · score 0.32
- Immature Reticulocyte Fraction Measurement · score 0.09
- hepatocellular carcinoma · score 0.08
- laryngotracheoesophageal cleft · score 0.07
- muscular disease · score 0.06
- waist-hip ratio · score 0.05
- type 2 diabetes mellitus · score 0.04
- sex interaction measurement · score 0.04
- sitting height measurement · score 0.04
- lymphocyte count · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O94876-F1 | alphafold | PREDICTED | 61.86 | — |
Amino-acid sequence (653 residues)
MEPSGSEQLF EDPDPGGKSQ DAEARKQTES EQKLSKMTHN ALENINVIGQ GLKHLFQHQR RRSSVSPHDV QQIQADPEPE MDLESQNACA EIDGVPTHPT ALNRVLQQIR VPPKMKRGTS LHSRRGKPEA PKGSPQINRK SGQEMTAVMQ SGRPRSSSTT DAPTSSAMME IACAAAAAAA ACLPGEEGTA ERIERLEVSS LAQTSSAVAS STDGSIHTDS VDGTPDPQRT KAAIAHLQQK ILKLTEQIKI AQTARDDNVA EYLKLANSAD KQQAARIKQV FEKKNQKSAQ TILQLQKKLE HYHRKLREVE QNGIPRQPKD VFRDMHQGLK DVGAKVTGFS EGVVDSVKGG FSSFSQATHS AAGAVVSKPR EIASLIRNKF GSADNIPNLK DSLEEGQVDD AGKALGVISN FQSSPKYGSE EDCSSATSGS VGANSTTGGI AVGASSSKTN TLDMQSSGFD ALLHEIQEIR ETQARLEESF ETLKEHYQRD YSLIMQTLQE ERYRCERLEE QLNDLTELHQ NEILNLKQEL ASMEEKIAYQ SYERARDIQE ALEACQTRIS KMELQQQQQQ VVQLEGLENA TARNLLGKLI NILLAVMAVL LVFVSTVANC VVPLMKTRNR TFSTLFLVVF IAFLWKHWDA LFSYVERFFS SPR
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