Tumor necrosis factor ligand superfamily member 15…

About Tumor necrosis factor ligand superfamily member 15

Tumor necrosis factor ligand superfamily member 15 (TNFSF15) is a protein from Homo sapiens identified by UniProt accession O95150, 251 residues long. MolForge cross-references it against 0 known binders and 386 disease associations.

Target properties

Protein name	Tumor necrosis factor ligand superfamily member 15
UniProt accession	O95150
Gene	TNFSF15
Organism	Homo sapiens
Length	251 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (386)

Diseases linked to this target (Open Targets).

inflammatory bowel disease · score 0.52
Crohn's disease · score 0.52
ulcerative colitis · score 0.50
leprosy · score 0.49
primary biliary cirrhosis · score 0.44
psoriasis · score 0.42
ankylosing spondylitis · score 0.41
autoimmune disease · score 0.35
common variable immunodeficiency · score 0.35
systemic lupus erythematosus · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95150-F1	alphafold	PREDICTED	81.07	—

Amino-acid sequence (251 residues)

MAEDLGLSFG ETASVEMLPE HGSCRPKARS SSARWALTCC LVLLPFLAGL TTYLLVSQLR AQGEACVQFQ ALKGQEFAPS HQQVYAPLRA DGDKPRAHLT VVRQTPTQHF KNQFPALHWE HELGLAFTKN RMNYTNKFLL IPESGDYFIY SQVTFRGMTS ECSEIRQAGR PNKPDSITVV ITKVTDSYPE PTQLLMGTKS VCEVGSNWFQ PIYLGAMFSL QEGDKLMVNV SDISLVDYTK EDKTFFGAFL L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Tumor necrosis factor ligand superfamily member 15 (TNFSF15)