5-hydroxytryptamine receptor 3B (HTR3B)

About 5-hydroxytryptamine receptor 3B

5-hydroxytryptamine receptor 3B (HTR3B) is a protein from Homo sapiens identified by UniProt accession O95264, 441 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	5-hydroxytryptamine receptor 3B
UniProt accession	O95264
Gene	HTR3B
Organism	Homo sapiens
Length	441 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (92)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.59
post operative nausea and vomiting · score 0.57
irritable bowel syndrome · score 0.54
type 2 diabetes mellitus · score 0.52
schizoaffective disorder · score 0.50
Nausea and vomiting · score 0.46
psychosis · score 0.46
cancer · score 0.44
Chemotherapy-induced nausea and vomiting · score 0.44
Nausea · score 0.43

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95264-F1	alphafold	PREDICTED	81.74	—

Amino-acid sequence (441 residues)

MLSSVMAPLW ACILVAAGIL ATDTHHPQDS ALYHLSKQLL QKYHKEVRPV YNWTKATTVY LDLFVHAILD VDAENQILKT SVWYQEVWND EFLSWNSSMF DEIREISLPL SAIWAPDIII NEFVDIERYP DLPYVYVNSS GTIENYKPIQ VVSACSLETY AFPFDVQNCS LTFKSILHTV EDVDLAFLRS PEDIQHDKKA FLNDSEWELL SVSSTYSILQ SSAGGFAQIQ FNVVMRRHPL VYVVSLLIPS IFLMLVDLGS FYLPPNCRAR IVFKTSVLVG YTVFRVNMSN QVPRSVGSTP LIGHFFTICM AFLVLSLAKS IVLVKFLHDE QRGGQEQPFL CLRGDTDADR PRVEPRAQRA VVTESSLYGE HLAQPGTLKE VWSQLQSISN YLQTQDQTDQ QEAEWLVLLS RFDRLLFQSY LFMLGIYTIT LCSLWALWGG V

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards