Ly6/PLAUR domain-containing protein 3 (LYPD3)

About Ly6/PLAUR domain-containing protein 3

Ly6/PLAUR domain-containing protein 3 (LYPD3) is a protein from Homo sapiens identified by UniProt accession O95274, 346 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.

Target properties

Protein name	Ly6/PLAUR domain-containing protein 3
UniProt accession	O95274
Gene	LYPD3
Organism	Homo sapiens
Length	346 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (75)

Diseases linked to this target (Open Targets).

head and neck squamous cell carcinoma · score 0.08
neoplasm · score 0.08
hepatocellular carcinoma · score 0.07
acute myeloid leukemia · score 0.07
melanoma · score 0.07
adolescent idiopathic scoliosis · score 0.06
laryngotracheoesophageal cleft · score 0.06
hypertriglyceridemia 2 · score 0.05
platelet count · score 0.05
cholesterol-ester transfer protein deficiency · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95274-F1	alphafold	PREDICTED	74.29	—

Amino-acid sequence (346 residues)

MDPARKAGAQ AMIWTAGWLL LLLLRGGAQA LECYSCVQKA DDGCSPNKMK TVKCAPGVDV CTEAVGAVET IHGQFSLAVR GCGSGLPGKN DRGLDLHGLL AFIQLQQCAQ DRCNAKLNLT SRALDPAGNE SAYPPNGVEC YSCVGLSREA CQGTSPPVVS CYNASDHVYK GCFDGNVTLT AANVTVSLPV RGCVQDEFCT RDGVTGPGFT LSGSCCQGSR CNSDLRNKTY FSPRIPPLVR LPPPEPTTVA STTSVTTSTS APVRPTSTTK PMPAPTSQTP RQGVEHEASR DEEPRLTGGA AGHQDRSNSG QYPAKGGPQQ PHNKGCVAPT AGLAALLLAV AAGVLL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards