About Acyl-protein thioesterase 2
Acyl-protein thioesterase 2 (LYPLA2) is a protein
from Homo sapiens identified by UniProt accession
O95372, 231 residues long.
MolForge cross-references it against 0 known binders and
17 disease associations.
Target properties
| Protein name | Acyl-protein thioesterase 2 |
|---|
| UniProt accession | O95372 |
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| Gene | LYPLA2 |
|---|
| Organism | Homo sapiens |
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| Length | 231 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (17)
Diseases linked to this target (Open Targets).
- thyroid disease · score 0.04
- lymphocyte count · score 0.04
- reticulocyte count · score 0.03
- body fat percentage · score 0.02
- myxedema · score 0.02
- mammographic density measurement · score 0.02
- hepatocellular carcinoma · score 0.01
- COVID-19 · score 0.01
- neoplasm · score 0.01
- calf circumference measurement · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95372-F1 | alphafold | PREDICTED | 95.70 | — |
Amino-acid sequence (231 residues)
MCGNTMSVPL LTDAATVSGA ERETAAVIFL HGLGDTGHSW ADALSTIRLP HVKYICPHAP RIPVTLNMKM VMPSWFDLMG LSPDAPEDEA GIKKAAENIK ALIEHEMKNG IPANRIVLGG FSQGGALSLY TALTCPHPLA GIVALSCWLP LHRAFPQAAN GSAKDLAILQ CHGELDPMVP VRFGALTAEK LRSVVTPARV QFKTYPGVMH SSCPQEMAAV KEFLEKLLPP V
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