Mitochondrial pyruvate carrier 2 (MPC2)

About Mitochondrial pyruvate carrier 2

Mitochondrial pyruvate carrier 2 (MPC2) is a protein from Homo sapiens identified by UniProt accession O95563, 127 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.

Target properties

Protein name	Mitochondrial pyruvate carrier 2
UniProt accession	O95563
Gene	MPC2
Organism	Homo sapiens
Length	127 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (59)

Diseases linked to this target (Open Targets).

sex hormone-binding globulin measurement · score 0.28
mitochondrial pyruvate carrier deficiency · score 0.19
schizophrenia · score 0.10
MODY · score 0.05
melanoma · score 0.05
hepatocellular carcinoma · score 0.04
exercise-induced hyperinsulinism · score 0.04
neoplasm · score 0.03
islet cell adenomatosis · score 0.03
protein measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95563-F1	alphafold	PREDICTED	89.41	—

Amino-acid sequence (127 residues)

MSAAGARGLR ATYHRLLDKV ELMLPEKLRP LYNHPAGPRT VFFWAPIMKW GLVCAGLADM ARPAEKLSTA QSAVLMATGF IWSRYSLVII PKNWSLFAVN FFVGAAGASQ LFRIWRYNQE LKAKAHK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards