Lonidamine

ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

Key facts

Lonidamine is a drug catalogued in DrugCentral. DrugCentral lists 3 molecular targets, including Mpc2, MPC2 and MPC1L. Recorded indications include Malignant tumor of lung.

• Molecular targets: Mpc2, MPC2 and MPC1L (3 listed in DrugCentral).
• Indications: Malignant tumor of lung.
• ATC code: L01XX07 (Other antineoplastic agents).
• Molecular formula: C15H10Cl2N2O2; molecular weight 321.16 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Malignant tumor of lung

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Mitochondrial pyruvate carrier 2	Mpc2	inhibitor	IC50 5.60
Mitochondrial pyruvate carrier 2	MPC2	inhibitor	IC50 5.34
Mitochondrial pyruvate carrier 1-like protein	MPC1L	inhibitor	IC50 5.34

ATC classification

ATC code	Therapeutic hierarchy
L01XX07	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › ANTINEOPLASTIC AGENTS › OTHER ANTINEOPLASTIC AGENTS › Other antineoplastic agents

Chemical structure

• Molecular formula: C₁₅H₁₀Cl₂N₂O₂
• Molecular weight: 321.16 g/mol
• CAS number: 50264-69-2
• InChIKey: WDRYRZXSPDWGEB-UHFFFAOYSA-N
• PubChem CID: 39562

OC(=O)C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C2=C1C=CC=C2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Lonidamine used for?

DrugCentral lists the following indications for Lonidamine: Malignant tumor of lung.

How does Lonidamine work?

Its molecular targets in DrugCentral include Mpc2 (inhibitor), MPC2 (inhibitor) and MPC1L (inhibitor).

What is the chemical formula of Lonidamine?

Lonidamine has the molecular formula C15H10Cl2N2O2 and a molecular weight of 321.16 g/mol.

Sources

• DrugCentral drug card 1598 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1257030 — compound record and bioactivity
• PubChem CID 39562 — chemical identifiers
• DrugBank DB06266 — drug record
• FDA UNII U78804BIDR — substance identity
• UniProt O95563 (MPC2) — target protein
• UniProt P0DKB6 (MPC1L) — target protein

How this page is built: methodology · editorial policy & corrections.