Neurotensin receptor type 2 (NTSR2)

About Neurotensin receptor type 2

Neurotensin receptor type 2 (NTSR2) is a protein from Homo sapiens identified by UniProt accession O95665, 410 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.

Target properties

Protein name	Neurotensin receptor type 2
UniProt accession	O95665
Gene	NTSR2
Organism	Homo sapiens
Length	410 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (64)

Diseases linked to this target (Open Targets).

breast adenocarcinoma · score 0.25
PHF-tau measurement · score 0.17
head and neck squamous cell carcinoma · score 0.16
body height · score 0.13
endometriosis · score 0.12
balding measurement · score 0.10
creatinine measurement · score 0.10
sex hormone-binding globulin measurement · score 0.10
age at menarche · score 0.10
testosterone measurement · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95665-F1	alphafold	PREDICTED	78.87	—

Amino-acid sequence (410 residues)

METSSPRPPR PSSNPGLSLD ARLGVDTRLW AKVLFTALYA LIWALGAAGN ALSAHVVLKA RAGRAGRLRH HVLSLALAGL LLLLVGVPVE LYSFVWFHYP WVFGDLGCRG YYFVHELCAY ATVLSVAGLS AERCLAVCQP LRARSLLTPR RTRWLVALSW AASLGLALPM AVIMGQKHEL ETADGEPEPA SRVCTVLVSR TALQVFIQVN VLVSFVLPLA LTAFLNGVTV SHLLALCSQV PSTSTPGSST PSRLELLSEE GLLSFIVWKK TFIQGGQVSL VRHKDVRRIR SLQRSVQVLR AIVVMYVICW LPYHARRLMY CYVPDDAWTD PLYNFYHYFY MVTNTLFYVS SAVTPLLYNA VSSSFRKLFL EAVSSLCGEH HPMKRLPPKP QSPTLMDTAS GFGDPPETRT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards