Levocabastine

RESPIRATORY SYSTEM

Key facts

Levocabastine is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1993. DrugCentral lists 5 molecular targets, including Ntsr2, Ntsr2 and HRH1. Recorded indications include Allergic conjunctivitis.

• Approval status: ofm (first approved 1993 by the FDA).
• Molecular targets: Ntsr2, Ntsr2, HRH1 and NTSR2 (5 listed in DrugCentral).
• Indications: Allergic conjunctivitis.
• ATC code: R01AC02 (Antiallergic agents, excl. corticosteroids).
• Molecular formula: C26H29FN2O2; molecular weight 420.53 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Allergic conjunctivitis

Mechanism & targets

Molecular targets (5)

Target	Gene	Action	Activity
Neurotensin receptor type 2	Ntsr2	agonist	IC50 8.70
Neurotensin receptor 2	Ntsr2	unknown	Ki 7.48
Histamine H1 receptor	HRH1	antagonist	Ki 7.28
Neurotensin receptor type 2	NTSR2	agonist	Ki 6.80
Multidrug resistance protein 1	ABCB1	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1993-11-10	FDA	—	NOVARTIS

ATC classification

ATC code	Therapeutic hierarchy
R01AC02	RESPIRATORY SYSTEM › NASAL PREPARATIONS › DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE › Antiallergic agents, excl. corticosteroids
S01GX02	SENSORY ORGANS › OPHTHALMOLOGICALS › DECONGESTANTS AND ANTIALLERGICS › Other antiallergics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Abdominal wall haematoma	22.1

Chemical structure

• Molecular formula: C₂₆H₂₉FN₂O₂
• Molecular weight: 420.53 g/mol
• CAS number: 79516-68-0
• InChIKey: ZCGOMHNNNFPNMX-KYTRFIICSA-N
• PubChem CID: 54385

C[C@@H]1CN(CC[C@]1(C(O)=O)C1=CC=CC=C1)[C@H]1CC[C@](CC1)(C#N)C1=CC=C(F)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Levocabastine used for?

DrugCentral lists the following indications for Levocabastine: Allergic conjunctivitis.

How does Levocabastine work?

Its molecular targets in DrugCentral include Ntsr2 (agonist), Ntsr2, HRH1 (antagonist) and NTSR2 (agonist).

When was Levocabastine first approved?

Levocabastine was first approved by the FDA in 1993.

What is the chemical formula of Levocabastine?

Levocabastine has the molecular formula C26H29FN2O2 and a molecular weight of 420.53 g/mol.

Sources

• DrugCentral drug card 1564 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1237102 — compound record and bioactivity
• PubChem CID 54385 — chemical identifiers
• DrugBank DB01106 — drug record
• FDA UNII H68BP06S81 — substance identity
• DailyMed: FDA labels for Levocabastine — current prescribing information (label search)
• UniProt P35367 (HRH1) — target protein
• UniProt O95665 (NTSR2) — target protein
• UniProt P08183 (ABCB1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.