Antazoline

RESPIRATORY SYSTEM

Key facts

Antazoline is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1990. DrugCentral lists 2 molecular targets, including HRH1 and HRH1. Recorded indications include Allergic conjunctivitis, Allergic rhinitis, Anaphylaxis Adjunct and Dermatographic urticaria.

• Approval status: ofm (first approved 1990 by the FDA).
• Molecular targets: HRH1 and HRH1 (2 listed in DrugCentral).
• Indications: Allergic conjunctivitis, Allergic rhinitis, Anaphylaxis Adjunct, Dermatographic urticaria and Itching of skin and others.
• ATC code: R01AC04 (Antiallergic agents, excl. corticosteroids).
• Molecular formula: C17H19N3; molecular weight 265.36 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (12)

• Allergic conjunctivitis
• Allergic rhinitis
• Anaphylaxis Adjunct
• Dermatographic urticaria
• Itching of skin
• Nasal congestion
• Nasal discharge
• Ocular Itching
• Red eye
• Sneezing
• Urticaria
• Vasomotor rhinitis

Contraindications (14)

• Angle-closure glaucoma
• Benign prostatic hyperplasia
• Bladder outflow obstruction
• Chronic idiopathic constipation
• Diabetes mellitus
• Disorder of cardiovascular system
• Eye infection
• Hyperglycemia
• Hypertensive disorder
• Hyperthyroidism
• Injury of eye region
• Ocular hypertension
• Peptic ulcer
• Retention of urine

Mechanism & targets

Molecular targets (2)

Target	Gene	Action	Activity
Histamine H1 receptor	HRH1	unknown	Kd 7.14
Histamine H1 receptor	HRH1	antagonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1990-04-30	FDA	—	NOVARTIS

ATC classification

ATC code	Therapeutic hierarchy
R01AC04	RESPIRATORY SYSTEM › NASAL PREPARATIONS › DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE › Antiallergic agents, excl. corticosteroids
R06AX05	RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Other antihistamines for systemic use

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Antazoline is on its molecule page.

• Molecular formula: C₁₇H₁₉N₃
• Molecular weight: 265.36 g/mol
• CAS number: —
• InChIKey: REYFJDPCWQRWAA-UHFFFAOYSA-N
• PubChem CID: 2200

C(N(CC1=CC=CC=C1)C1=CC=CC=C1)C1=NCCN1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Antazoline used for?

DrugCentral lists the following indications for Antazoline: Allergic conjunctivitis, Allergic rhinitis, Anaphylaxis Adjunct, Dermatographic urticaria, Itching of skin, Nasal congestion, Nasal discharge and Ocular Itching and others.

How does Antazoline work?

Its molecular targets in DrugCentral include HRH1 and HRH1 (antagonist).

When was Antazoline first approved?

Antazoline was first approved by the FDA in 1990.

What is the chemical formula of Antazoline?

Antazoline has the molecular formula C17H19N3 and a molecular weight of 265.36 g/mol.

Sources

• DrugCentral drug card 224 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200550 — compound record and bioactivity
• PubChem CID 2200 — chemical identifiers
• DrugBank DB08799 — drug record
• FDA UNII DHA8014SS1 — substance identity
• DailyMed: FDA labels for Antazoline — current prescribing information (label search)
• UniProt P35367 (HRH1) — target protein

How this page is built: methodology · editorial policy & corrections.