Lodoxamide

Mast Cell Stabilizer — SENSORY ORGANS

Key facts

Lodoxamide is an ofm drug in the Mast Cell Stabilizer class catalogued in DrugCentral. It was first approved by the FDA in 1993. DrugCentral lists 1 molecular target, including GPR35. Recorded indications include Vernal conjunctivitis, Vernal Keratitis and Vernal keratoconjunctivitis.

• Approval status: ofm (first approved 1993 by the FDA).
• Drug class: Mast Cell Stabilizer.
• Molecular targets: GPR35 (1 listed in DrugCentral).
• Indications: Vernal conjunctivitis, Vernal Keratitis and Vernal keratoconjunctivitis.
• ATC code: S01GX05 (Other antiallergics).
• Molecular formula: C11H6ClN3O6; molecular weight 311.64 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• Vernal conjunctivitis
• Vernal Keratitis
• Vernal keratoconjunctivitis

Off-label uses (3)

• Allergic conjunctivitis
• Allergic Keratoconjunctivitis
• Giant papillary conjunctivitis

Mechanism & targets

• Established pharmacologic class: Mast Cell Stabilizer

Molecular targets (1)

Target	Gene	Action	Activity
G-protein coupled receptor 35	GPR35	agonist	EC50 8.79

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1993-09-23	FDA	—	ALCON	Yes

ATC classification

ATC code	Therapeutic hierarchy
S01GX05	SENSORY ORGANS › OPHTHALMOLOGICALS › DECONGESTANTS AND ANTIALLERGICS › Other antiallergics

Chemical structure

• Molecular formula: C₁₁H₆ClN₃O₆
• Molecular weight: 311.64 g/mol
• CAS number: —
• InChIKey: RVGLGHVJXCETIO-UHFFFAOYSA-N
• PubChem CID: 44564

OC(=O)C(=O)NC1=CC(=CC(NC(=O)C(O)=O)=C1Cl)C#N

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Lodoxamide used for?

DrugCentral lists the following indications for Lodoxamide: Vernal conjunctivitis, Vernal Keratitis and Vernal keratoconjunctivitis.

How does Lodoxamide work?

Its molecular targets in DrugCentral include GPR35 (agonist).

When was Lodoxamide first approved?

Lodoxamide was first approved by the FDA in 1993.

What drug class does Lodoxamide belong to?

Lodoxamide is in the Mast Cell Stabilizer class.

What is the chemical formula of Lodoxamide?

Lodoxamide has the molecular formula C11H6ClN3O6 and a molecular weight of 311.64 g/mol.

Sources

• DrugCentral drug card 3325 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1201266 — compound record and bioactivity
• PubChem CID 44564 — chemical identifiers
• DrugBank DB06794 — drug record
• FDA UNII SPU695OD73 — substance identity
• DailyMed: FDA labels for Lodoxamide — current prescribing information (label search)
• UniProt Q9HC97 (GPR35) — target protein

How this page is built: methodology · editorial policy & corrections.