Emedastine
Histamine-1 Receptor Inhibitor — SENSORY ORGANS
Also known as: daren, emadine, emedastine difumarate, emedastine difumarate ophthalmic solution, emedastine fumarate
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Emedastine is an ofm drug in the Histamine-1 Receptor Inhibitor class catalogued in DrugCentral. It was first approved by the FDA in 1997. Its mechanism of action is classified as Histamine H1 Receptor Antagonists. DrugCentral lists 1 molecular target, including HRH1. Recorded indications include Allergic conjunctivitis, Itching of skin and Urticaria.
- Approval status: ofm (first approved 1997 by the FDA).
- Drug class: Histamine-1 Receptor Inhibitor.
- Mechanism of action: Histamine H1 Receptor Antagonists.
- Molecular targets: HRH1 (1 listed in DrugCentral).
- Indications: Allergic conjunctivitis, Itching of skin and Urticaria.
- ATC code: S01GX06 (Other antiallergics).
- Molecular formula: C17H26N4O; molecular weight 302.42 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (3)
- Allergic conjunctivitis
- Itching of skin
- Urticaria
Mechanism & targets
| Mechanism of action (MoA) | Histamine H1 Receptor Antagonists |
|---|---|
| Established pharmacologic class | Histamine-1 Receptor Inhibitor |
Molecular targets (1)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Histamine H1 receptor | HRH1 | antagonist | Ki 8.89 |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1997-12-29 | FDA | — | ALCON |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
S01GX06 | SENSORY ORGANS › OPHTHALMOLOGICALS › DECONGESTANTS AND ANTIALLERGICS › Other antiallergics |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Emedastine is on its molecule page.
| Molecular formula | C17H26N4O |
|---|---|
| Molecular weight | 302.42 g/mol |
| CAS number | 87233-61-2 |
| InChIKey | KBUZBQVCBVDWKX-UHFFFAOYSA-N |
| PubChem CID | 3219 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Emedastine used for?
DrugCentral lists the following indications for Emedastine: Allergic conjunctivitis, Itching of skin and Urticaria.
How does Emedastine work?
Emedastine is classified as Histamine H1 Receptor Antagonists; its molecular targets in DrugCentral include HRH1 (antagonist).
When was Emedastine first approved?
Emedastine was first approved by the FDA in 1997.
What drug class does Emedastine belong to?
Emedastine is in the Histamine-1 Receptor Inhibitor class.
What is the chemical formula of Emedastine?
Emedastine has the molecular formula C17H26N4O and a molecular weight of 302.42 g/mol.
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Sources
- DrugCentral drug card 999 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL2103739 — compound record and bioactivity
- PubChem CID 3219 — chemical identifiers
- DrugBank DB01084 — drug record
- FDA UNII 9J1H7Y9OJV — substance identity
- DailyMed: FDA labels for Emedastine — current prescribing information (label search)
- UniProt P35367 (HRH1) — target protein
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