Nedocromil

Mast Cell Stabilizer — RESPIRATORY SYSTEM

Key facts

Nedocromil is an ofm drug in the Mast Cell Stabilizer class catalogued in DrugCentral. It was first approved by the FDA in 1992. DrugCentral lists 2 molecular targets, including GPR35 and CYSLTR1. Recorded indications include Allergic conjunctivitis, Asthma, Asthma management and Ocular Itching.

• Approval status: ofm (first approved 1992 by the FDA).
• Drug class: Mast Cell Stabilizer.
• Molecular targets: GPR35 and CYSLTR1 (2 listed in DrugCentral).
• Indications: Allergic conjunctivitis, Asthma, Asthma management and Ocular Itching.
• ATC code: R01AC07 (Antiallergic agents, excl. corticosteroids).
• Molecular formula: C19H17NO7; molecular weight 371.35 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (4)

• Allergic conjunctivitis
• Asthma
• Asthma management
• Ocular Itching

Off-label uses (1)

• Bronchospasm Prevention

Mechanism & targets

• Established pharmacologic class: Mast Cell Stabilizer

Molecular targets (2)

Target	Gene	Action	Activity
G-protein coupled receptor 35	GPR35	agonist	EC50 6.01
Cysteinyl leukotriene receptor 1	CYSLTR1	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1992-12-30	FDA	—	KING PHARMS

ATC classification

ATC code	Therapeutic hierarchy
R01AC07	RESPIRATORY SYSTEM › NASAL PREPARATIONS › DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE › Antiallergic agents, excl. corticosteroids
R03BC03	RESPIRATORY SYSTEM › DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES › OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS › Antiallergic agents, excl. corticosteroids
S01GX04	SENSORY ORGANS › OPHTHALMOLOGICALS › DECONGESTANTS AND ANTIALLERGICS › Other antiallergics

Chemical structure

• Molecular formula: C₁₉H₁₇NO₇
• Molecular weight: 371.35 g/mol
• CAS number: 69049-73-6
• InChIKey: RQTOOFIXOKYGAN-UHFFFAOYSA-N
• PubChem CID: 50294

CCCC1=C2N(CC)C(=CC(=O)C2=CC2=C1OC(=CC2=O)C(O)=O)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Nedocromil used for?

DrugCentral lists the following indications for Nedocromil: Allergic conjunctivitis, Asthma, Asthma management and Ocular Itching.

How does Nedocromil work?

Its molecular targets in DrugCentral include GPR35 (agonist) and CYSLTR1.

When was Nedocromil first approved?

Nedocromil was first approved by the FDA in 1992.

What drug class does Nedocromil belong to?

Nedocromil is in the Mast Cell Stabilizer class.

What is the chemical formula of Nedocromil?

Nedocromil has the molecular formula C19H17NO7 and a molecular weight of 371.35 g/mol.

Sources

• DrugCentral drug card 1889 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL746 — compound record and bioactivity
• PubChem CID 50294 — chemical identifiers
• DrugBank DB00716 — drug record
• FDA UNII 0B535E0BN0 — substance identity
• DailyMed: FDA labels for Nedocromil — current prescribing information (label search)
• UniProt Q9HC97 (GPR35) — target protein
• UniProt Q9Y271 (CYSLTR1) — target protein

How this page is built: methodology · editorial policy & corrections.