Cysteinyl leukotriene receptor 1 (CYSLTR1)

About Cysteinyl leukotriene receptor 1

Cysteinyl leukotriene receptor 1 (CYSLTR1) is a protein from Homo sapiens identified by UniProt accession Q9Y271, 337 residues long. MolForge cross-references it against 0 known binders and 238 disease associations.

Target properties

Protein name	Cysteinyl leukotriene receptor 1
UniProt accession	Q9Y271
Gene	CYSLTR1
Organism	Homo sapiens
Length	337 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (7)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (238)

Diseases linked to this target (Open Targets).

asthma · score 0.61
allergic rhinitis · score 0.60
seasonal allergic rhinitis · score 0.59
Rhinitis, Allergic, Perennial · score 0.56
obstructive sleep apnea · score 0.53
Airway obstruction · score 0.53
COVID-19 · score 0.52
Cough · score 0.47
acute coronary syndrome · score 0.46
bronchoconstriction · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y271-F1	alphafold	PREDICTED	85.66	—

Amino-acid sequence (337 residues)

MDETGNLTVS SATCHDTIDD FRNQVYSTLY SMISVVGFFG NGFVLYVLIK TYHKKSAFQV YMINLAVADL LCVCTLPLRV VYYVHKGIWL FGDFLCRLST YALYVNLYCS IFFMTAMSFF RCIAIVFPVQ NINLVTQKKA RFVCVGIWIF VILTSSPFLM AKPQKDEKNN TKCFEPPQDN QTKNHVLVLH YVSLFVGFII PFVIIIVCYT MIILTLLKKS MKKNLSSHKK AIGMIMVVTA AFLVSFMPYH IQRTIHLHFL HNETKPCDSV LRMQKSVVIT LSLAASNCCF DPLLYFFSGG NFRKRLSTFR KHSLSSVTYV PRKKASLPEK GEEICKV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards