G-protein coupled receptor 35 (GPR35)
Homo sapiens — UniProt Q9HC97
Data last refreshed: (UniProt release unknown)
Key facts
G-protein coupled receptor 35 (GPR35) is a protein from Homo sapiens identified by UniProt accession Q9HC97, 309 residues long. MolForge cross-references it against 11 known binders and 146 disease associations.
- UniProt accession: Q9HC97; gene symbol GPR35.
- Organism: Homo sapiens.
- Length: 309 amino acids.
- Approved drugs acting on it (DrugCentral): Lodoxamide, Nedocromil and Bumetanide.
- Top disease associations (Open Targets): ulcerative colitis, inflammatory bowel disease and monocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | G-protein coupled receptor 35 |
|---|---|
| UniProt accession | Q9HC97 |
| Gene | GPR35 |
| Organism | Homo sapiens |
| Length | 309 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (3)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (146)
Diseases linked to this target (Open Targets).
- ulcerative colitis · score 0.46
- inflammatory bowel disease · score 0.44
- monocyte count · score 0.43
- eosinophil count · score 0.39
- monocyte percentage of leukocytes · score 0.38
- Crohn's disease · score 0.37
- sclerosing cholangitis · score 0.36
- ankylosing spondylitis · score 0.36
- psoriasis · score 0.29
- interstitial lung disease · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9HC97-F1 | alphafold | PREDICTED | 84.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9HC97.
Amino-acid sequence (309 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target GPR35?
DrugCentral lists 3 approved drugs whose mechanism of action is GPR35: Lodoxamide, Nedocromil and Bumetanide.
Which diseases are associated with GPR35?
The strongest Open Targets associations for GPR35 are ulcerative colitis, inflammatory bowel disease, monocyte count, eosinophil count and monocyte percentage of leukocytes.
How long is the GPR35 protein?
The Homo sapiens GPR35 protein (UniProt Q9HC97) is 309 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9HC97 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9HC97 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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