Bumetanide

Loop Diuretic — CARDIOVASCULAR SYSTEM

Key facts

Bumetanide is an ofp drug in the Loop Diuretic class catalogued in DrugCentral. It was first approved by the FDA in 1983. DrugCentral lists 5 molecular targets, including SLC12A1, ATP1A1 and SLC12A2. Recorded indications include Edema, Edema due to Hepatic Cirrhosis, Peripheral Edema due to Chronic Heart Failure and Pulmonary Edema due to Chronic Heart Failure.

• Approval status: ofp (first approved 1983 by the FDA).
• Drug class: Loop Diuretic.
• Molecular targets: SLC12A1, ATP1A1, SLC12A2 and GPR35 (5 listed in DrugCentral).
• Indications: Edema, Edema due to Hepatic Cirrhosis, Peripheral Edema due to Chronic Heart Failure, Pulmonary Edema due to Chronic Heart Failure and Renal Disease with Edema.
• ATC code: C03CA02 (Sulfonamides, plain).
• Molecular formula: C17H20N2O5S; molecular weight 364.42 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (5)

• Edema
• Edema due to Hepatic Cirrhosis
• Peripheral Edema due to Chronic Heart Failure
• Pulmonary Edema due to Chronic Heart Failure
• Renal Disease with Edema

Off-label uses (3)

• Decompensated cardiac failure
• Hypercalcemia
• Hypertensive disorder

Contraindications (12)

• Anuria
• Diabetes mellitus
• Disease of liver
• Hearing disorder
• Hepatic coma
• Hyperuricemia
• Hypocalcemia
• Hypokalemia
• Hypomagnesemia
• Hypovolemia
• Oliguria
• Thrombocytopenic disorder

Mechanism & targets

• Established pharmacologic class: Loop Diuretic

Molecular targets (5)

Target	Gene	Action	Activity
Solute carrier family 12 member 1	SLC12A1	inhibitor	Ki 7.60
Sodium/potassium-transporting ATPase subunit alpha-1	ATP1A1	unknown	Kd 7.52
Solute carrier family 12 member 2	SLC12A2	inhibitor	IC50 5.60
G-protein coupled receptor 35	GPR35	agonist	EC50 5.54
Carbonic anhydrase 2	CA2	unknown	Ki 5.16

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1983-02-28	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
C03CA02	CARDIOVASCULAR SYSTEM › DIURETICS › HIGH-CEILING DIURETICS › Sulfonamides, plain
C03CB02	CARDIOVASCULAR SYSTEM › DIURETICS › HIGH-CEILING DIURETICS › Sulfonamides and potassium in combination
C03EB02	CARDIOVASCULAR SYSTEM › DIURETICS › DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION › High-ceiling diuretics and potassium-sparing agents

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Acute kidney injury	861.3
Cardiac failure congestive	566.2
Dyspnoea	418.3
Hypervolaemia	403.6
Fluid retention	344.3
Cardiac failure	334.7
Pulmonary hypertension	267.0
Pulmonary arterial hypertension	228.1
Renal failure	214.1
Drug ineffective	209.8
Right ventricular failure	209.3
Hypotension	193.8

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Bumetanide is on its molecule page.

• Molecular formula: C₁₇H₂₀N₂O₅S
• Molecular weight: 364.42 g/mol
• CAS number: —
• InChIKey: MAEIEVLCKWDQJH-UHFFFAOYSA-N
• PubChem CID: 2471

CCCCNC1=C(OC2=CC=CC=C2)C(=CC(=C1)C(O)=O)S(N)(=O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Bumetanide used for?

DrugCentral lists the following indications for Bumetanide: Edema, Edema due to Hepatic Cirrhosis, Peripheral Edema due to Chronic Heart Failure, Pulmonary Edema due to Chronic Heart Failure and Renal Disease with Edema.

How does Bumetanide work?

Its molecular targets in DrugCentral include SLC12A1 (inhibitor), ATP1A1, SLC12A2 (inhibitor) and GPR35 (agonist).

When was Bumetanide first approved?

Bumetanide was first approved by the FDA in 1983.

What drug class does Bumetanide belong to?

Bumetanide is in the Loop Diuretic class.

What is the chemical formula of Bumetanide?

Bumetanide has the molecular formula C17H20N2O5S and a molecular weight of 364.42 g/mol.

Sources

• DrugCentral drug card 427 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1072 — compound record and bioactivity
• PubChem CID 2471 — chemical identifiers
• DrugBank DB00887 — drug record
• FDA UNII 0Y2S3XUQ5H — substance identity
• DailyMed: FDA labels for Bumetanide — current prescribing information (label search)
• UniProt Q13621 (SLC12A1) — target protein
• UniProt P05023 (ATP1A1) — target protein
• UniProt P55011 (SLC12A2) — target protein
• UniProt Q9HC97 (GPR35) — target protein
• UniProt P00918 (CA2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.