Alcaftadine

Histamine-1 Receptor Antagonist — SENSORY ORGANS

Key facts

Alcaftadine is an ofp drug in the Histamine-1 Receptor Antagonist class catalogued in DrugCentral. It was first approved by the FDA in 2010. Its mechanism of action is classified as Histamine H1 Receptor Antagonists. DrugCentral lists 1 molecular target, including HRH1. Recorded indications include Allergic conjunctivitis.

• Approval status: ofp (first approved 2010 by the FDA).
• Drug class: Histamine-1 Receptor Antagonist.
• Mechanism of action: Histamine H1 Receptor Antagonists.
• Molecular targets: HRH1 (1 listed in DrugCentral).
• Indications: Allergic conjunctivitis.
• ATC code: S01GX11 (Other antiallergics).
• Molecular formula: C19H21N3O; molecular weight 307.40 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Allergic conjunctivitis

Mechanism & targets

• Mechanism of action (MoA): Histamine H1 Receptor Antagonists
• Established pharmacologic class: Histamine-1 Receptor Antagonist

Molecular targets (1)

Target	Gene	Action	Activity
Histamine H1 receptor	HRH1	antagonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2010-07-28	FDA	—	ALLERGAN

ATC classification

ATC code	Therapeutic hierarchy
S01GX11	SENSORY ORGANS › OPHTHALMOLOGICALS › DECONGESTANTS AND ANTIALLERGICS › Other antiallergics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Ocular hyperaemia	573.5
Eye irritation	269.1
Scleral hyperaemia	170.6
Eye swelling	136.9
Eye pruritus	116.6
Eyelid oedema	106.9
Eye pain	104.0
Erythema of eyelid	94.8

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Alcaftadine is on its molecule page.

• Molecular formula: C₁₉H₂₁N₃O
• Molecular weight: 307.40 g/mol
• CAS number: 147084-10-4
• InChIKey: MWTBKTRZPHJQLH-UHFFFAOYSA-N
• PubChem CID: 19371515

CN1CCC(CC1)=C1C2=NC=C(C=O)N2CCC2=C1C=CC=C2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Alcaftadine used for?

DrugCentral lists the following indications for Alcaftadine: Allergic conjunctivitis.

How does Alcaftadine work?

Alcaftadine is classified as Histamine H1 Receptor Antagonists; its molecular targets in DrugCentral include HRH1 (antagonist).

When was Alcaftadine first approved?

Alcaftadine was first approved by the FDA in 2010.

What drug class does Alcaftadine belong to?

Alcaftadine is in the Histamine-1 Receptor Antagonist class.

What is the chemical formula of Alcaftadine?

Alcaftadine has the molecular formula C19H21N3O and a molecular weight of 307.40 g/mol.

Sources

• DrugCentral drug card 4165 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1201747 — compound record and bioactivity
• PubChem CID 19371515 — chemical identifiers
• DrugBank DB06766 — drug record
• FDA UNII 7Z8O94ECSX — substance identity
• DailyMed: FDA labels for Alcaftadine — current prescribing information (label search)
• UniProt P35367 (HRH1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.