U6 snRNA-associated Sm-like protein LSm8 (LSM8)

About U6 snRNA-associated Sm-like protein LSm8

U6 snRNA-associated Sm-like protein LSm8 (LSM8) is a protein from Homo sapiens identified by UniProt accession O95777, 96 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	U6 snRNA-associated Sm-like protein LSm8
UniProt accession	O95777
Gene	LSM8
Organism	Homo sapiens
Length	96 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

gut microbiome measurement · score 0.27
triglyceride measurement · score 0.22
open-angle glaucoma · score 0.08
intraocular pressure measurement · score 0.07
gonorrhea · score 0.04
Burkitts lymphoma · score 0.03
neuroimaging measurement · score 0.03
glaucoma · score 0.03
brain measurement · score 0.03
white matter microstructure measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95777-F1	alphafold	PREDICTED	95.47	—

Amino-acid sequence (96 residues)

MTSALENYIN RTVAVITSDG RMIVGTLKGF DQTINLILDE SHERVFSSSQ GVEQVVLGLY IVRGDNVAVI GEIDEETDSA LDLGNIRAEP LNSVAH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards