About Double-stranded RNA-binding protein Staufen homolog 1
Double-stranded RNA-binding protein Staufen homolog 1 (STAU1) is a protein
from Homo sapiens identified by UniProt accession
O95793, 577 residues long.
MolForge cross-references it against 0 known binders and
90 disease associations.
Target properties
| Protein name | Double-stranded RNA-binding protein Staufen homolog 1 |
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| UniProt accession | O95793 |
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| Gene | STAU1 |
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| Organism | Homo sapiens |
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| Length | 577 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (90)
Diseases linked to this target (Open Targets).
- self reported educational attainment · score 0.24
- vital capacity · score 0.23
- intelligence · score 0.22
- aspartate aminotransferase measurement · score 0.22
- insomnia measurement · score 0.20
- depressive symptom measurement · score 0.19
- wellbeing measurement · score 0.19
- appendicular lean mass · score 0.19
- forced expiratory volume · score 0.17
- unipolar depression · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95793-F1 | alphafold | PREDICTED | 68.46 | — |
Amino-acid sequence (577 residues)
MSQVQVQVQN PSAALSGSQI LNKNQSLLSQ PLMSIPSTTS SLPSENAGRP IQNSALPSAS ITSTSAAAES ITPTVELNAL CMKLGKKPMY KPVDPYSRMQ STYNYNMRGG AYPPRYFYPF PVPPLLYQVE LSVGGQQFNG KGKTRQAAKH DAAAKALRIL QNEPLPERLE VNGRESEEEN LNKSEISQVF EIALKRNLPV NFEVARESGP PHMKNFVTKV SVGEFVGEGE GKSKKISKKN AAIAVLEELK KLPPLPAVER VKPRIKKKTK PIVKPQTSPE YGQGINPISR LAQIQQAKKE KEPEYTLLTE RGLPRRREFV MQVKVGNHTA EGTGTNKKVA KRNAAENMLE ILGFKVPQAQ PTKPALKSEE KTPIKKPGDG RKVTFFEPGS GDENGTSNKE DEFRMPYLSH QQLPAGILPM VPEVAQAVGV SQGHHTKDFT RAAPNPAKAT VTAMIARELL YGGTSPTAET ILKNNISSGH VPHGPLTRPS EQLDYLSRVQ GFQVEYKDFP KNNKNEFVSL INCSSQPPLI SHGIGKDVES CHDMAALNIL KLLSELDQQS TEMPRTGNGP MSVCGRC
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