About Claudin-1
Claudin-1 (CLDN1) is a protein
from Homo sapiens identified by UniProt accession
O95832, 211 residues long.
MolForge cross-references it against 0 known binders and
591 disease associations.
Target properties
| Protein name | Claudin-1 |
|---|
| UniProt accession | O95832 |
|---|
| Gene | CLDN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 211 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (591)
Diseases linked to this target (Open Targets).
- neonatal ichthyosis-sclerosing cholangitis syndrome · score 0.74
- neurodegenerative disease · score 0.30
- optic disc size measurement · score 0.26
- endometrial cancer · score 0.23
- genetic disorder · score 0.19
- neoplasm · score 0.11
- retinitis pigmentosa · score 0.11
- triple-negative breast cancer · score 0.10
- hepatocellular carcinoma · score 0.10
- age-related macular degeneration · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O95832-F1 | alphafold | PREDICTED | 84.73 | — |
Amino-acid sequence (211 residues)
MANAGLQLLG FILAFLGWIG AIVSTALPQW RIYSYAGDNI VTAQAMYEGL WMSCVSQSTG QIQCKVFDSL LNLSSTLQAT RALMVVGILL GVIAIFVATV GMKCMKCLED DEVQKMRMAV IGGAIFLLAG LAILVATAWY GNRIVQEFYD PMTPVNARYE FGQALFTGWA AASLCLLGGA LLCCSCPRKT TSYPTPRPYP KPAPSSGKDY V
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