Mitochondrial uncoupling protein 4 (SLC25A27)

About Mitochondrial uncoupling protein 4

Mitochondrial uncoupling protein 4 (SLC25A27) is a protein from Homo sapiens identified by UniProt accession O95847, 323 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	Mitochondrial uncoupling protein 4
UniProt accession	O95847
Gene	SLC25A27
Organism	Homo sapiens
Length	323 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

lipoprotein-associated phospholipase A(2) measurement · score 0.17
sterol measurement · score 0.08
lung adenocarcinoma · score 0.05
pancreatic adenocarcinoma · score 0.03
microphthalmia with limb anomalies · score 0.03
breast carcinoma · score 0.03
neuroblastoma · score 0.03
schizophrenia · score 0.03
Autism · score 0.02
ovarian carcinoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O95847-F1	alphafold	PREDICTED	81.05	—

Amino-acid sequence (323 residues)

MSVPEEEERL LPLTQRWPRA SKFLLSGCAA TVAELATFPL DLTKTRLQMQ GEAALARLGD GARESAPYRG MVRTALGIIE EEGFLKLWQG VTPAIYRHVV YSGGRMVTYE HLREVVFGKS EDEHYPLWKS VIGGMMAGVI GQFLANPTDL VKVQMQMEGK RKLEGKPLRF RGVHHAFAKI LAEGGIRGLW AGWVPNIQRA ALVNMGDLTT YDTVKHYLVL NTPLEDNIMT HGLSSLCSGL VASILGTPAD VIKSRIMNQP RDKQGRGLLY KSSTDCLIQA VQGEGFMSLY KGFLPSWLRM TPWSMVFWLT YEKIREMSGV SPF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards