Peroxisomal membrane protein 11B (PEX11B)

About Peroxisomal membrane protein 11B

Peroxisomal membrane protein 11B (PEX11B) is a protein from Homo sapiens identified by UniProt accession O96011, 259 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	Peroxisomal membrane protein 11B
UniProt accession	O96011
Gene	PEX11B
Organism	Homo sapiens
Length	259 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

peroxisome biogenesis disorder 14B · score 0.77
peroxisome biogenesis disorder · score 0.49
neurodegenerative disease · score 0.49
Zellweger syndrome · score 0.37
Intellectual disability · score 0.37
peroxisome biogenesis disorder, complementation group 7 · score 0.37
Peroxisome biogenesis disorder-Zellweger syndrome spectrum · score 0.27
Thrombocytopenia - absent radius · score 0.26
genetic disorder · score 0.19
neurogenic locus notch homolog protein 2 measurement · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O96011-F1	alphafold	PREDICTED	88.82	—

Amino-acid sequence (259 residues)

MDAWVRFSAQ SQARERLCRA AQYACSLLGH ALQRHGASPE LQKQIRQLES HLSLGRKLLR LGNSADALES AKRAVHLSDV VLRFCITVSH LNRALYFACD NVLWAGKSGL APRVDQEKWA QRSFRYYLFS LIMNLSRDAY EIRLLMEQES SACSRRLKGS GGGVPGGSET GGLGGPGTPG GGLPQLALKL RLQVLLLARV LRGHPPLLLD VVRNACDLFI PLDKLGLWRC GPGIVGLCGL VSSILSILTL IYPWLRLKP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards