About Serine/threonine-protein kinase Chk2
Serine/threonine-protein kinase Chk2 (CHEK2) is a protein
from Homo sapiens identified by UniProt accession
O96017, 543 residues long.
MolForge cross-references it against 0 known binders and
577 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase Chk2 |
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| UniProt accession | O96017 |
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| Gene | CHEK2 |
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| Organism | Homo sapiens |
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| Length | 543 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (577)
Diseases linked to this target (Open Targets).
- breast neoplasm · score 0.81
- hereditary breast carcinoma · score 0.79
- breast cancer · score 0.76
- prostate carcinoma · score 0.73
- Li-Fraumeni syndrome · score 0.71
- breast carcinoma · score 0.71
- bone osteosarcoma · score 0.70
- Familial prostate cancer · score 0.68
- Hereditary breast cancer · score 0.66
- neoplasm · score 0.65
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O96017-F1 | alphafold | PREDICTED | 76.18 | — |
Amino-acid sequence (543 residues)
MSRESDVEAQ QSHGSSACSQ PHGSVTQSQG SSSQSQGISS SSTSTMPNSS QSSHSSSGTL SSLETVSTQE LYSIPEDQEP EDQEPEEPTP APWARLWALQ DGFANLECVN DNYWFGRDKS CEYCFDEPLL KRTDKYRTYS KKHFRIFREV GPKNSYIAYI EDHSGNGTFV NTELVGKGKR RPLNNNSEIA LSLSRNKVFV FFDLTVDDQS VYPKALRDEY IMSKTLGSGA CGEVKLAFER KTCKKVAIKI ISKRKFAIGS AREADPALNV ETEIEILKKL NHPCIIKIKN FFDAEDYYIV LELMEGGELF DKVVGNKRLK EATCKLYFYQ MLLAVQYLHE NGIIHRDLKP ENVLLSSQEE DCLIKITDFG HSKILGETSL MRTLCGTPTY LAPEVLVSVG TAGYNRAVDC WSLGVILFIC LSGYPPFSEH RTQVSLKDQI TSGKYNFIPE VWAEVSEKAL DLVKKLLVVD PKARFTTEEA LRHPWLQDED MKRKFQDLLS EENESTALPQ VLAQPSTSRK RPREGEAEGA ETTKRPAVCA AVL
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