About Glutamate dehydrogenase 1, mitochondrial
Glutamate dehydrogenase 1, mitochondrial (GLUD1) is a protein
from Homo sapiens identified by UniProt accession
P00367, 558 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | Glutamate dehydrogenase 1, mitochondrial |
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| UniProt accession | P00367 |
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| Gene | GLUD1 |
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| Organism | Homo sapiens |
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| Length | 558 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (89)
Diseases linked to this target (Open Targets).
- hyperinsulinism-hyperammonemia syndrome · score 0.84
- epilepsy · score 0.37
- neurodegenerative disease · score 0.28
- gout · score 0.21
- uric acid measurement · score 0.20
- urate measurement · score 0.19
- hemoglobin measurement · score 0.19
- genetic disorder · score 0.19
- hematocrit · score 0.18
- erythrocyte count · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P00367-F1 | alphafold | PREDICTED | 90.22 | — |
Amino-acid sequence (558 residues)
MYRYLGEALL LSRAGPAALG SASADSAALL GWARGQPAAA PQPGLALAAR RHYSEAVADR EDDPNFFKMV EGFFDRGASI VEDKLVEDLR TRESEEQKRN RVRGILRIIK PCNHVLSLSF PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG GAKAGVKINP KNYTDNELEK ITRRFTMELA KKGFIGPGID VPAPDMSTGE REMSWIADTY ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGFG DKTFVVQGFG NVGLHSMRYL HRFGAKCIAV GESDGSIWNP DGIDPKELED FKLQHGSILG FPKAKPYEGS ILEADCDILI PAASEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER NIMVIPDLYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLMSV QESLERKFGK HGGTIPIVPT AEFQDRISGA SEKDIVHSGL AYTMERSARQ IMRTAMKYNL GLDLRTAAYV NAIEKVFKVY NEAGVTFT
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