Glutamic acid

ALIMENTARY TRACT AND METABOLISM

Key facts

Glutamic acid is a drug catalogued in DrugCentral. DrugCentral lists 43 molecular targets, including GRIK4, Grm8 and GRM3.

• Molecular targets: GRIK4, Grm8, GRM3 and SLC1A1 (43 listed in DrugCentral).
• ATC code: A09AB01 (Acid preparations).
• Molecular formula: C5H9NO4; molecular weight 147.13 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Contraindications (13)

• Classical phenylketonuria
• Dehydration
• End stage renal disease
• Heart disease
• Humoral hypercalcemia of malignancy
• Hypercalcemia
• Hypercalciuria
• Hyperparathyroidism
• Kidney disease
• Kidney stone
• Poisoning by digitalis glycoside
• Sarcoidosis
• Ventricular fibrillation

Mechanism & targets

Molecular targets (43)

Target	Gene	Action	Activity
Glutamate receptor ionotropic, kainate 4	GRIK4	unknown	Ki 7.74
Metabotropic glutamate receptor 8	Grm8	unknown	EC50 7.66
Metabotropic glutamate receptor 3	GRM3	agonist	Ki 7.40
Excitatory amino acid transporter 3	SLC1A1	unknown	Ki 7.29
Glutamate receptor ionotropic, kainate 1	Grik1	unknown	Ki 6.85
Metabotropic glutamate receptor 1	GRM1	unknown	Ki 6.60
Glutamate receptor 3	GRIA3	unknown	Ki 6.59
Glutamate receptor 2	Gria2	unknown	Ki 6.55
Metabotropic glutamate receptor 2	GRM2	unknown	EC50 6.54
Metabotropic glutamate receptor 5	GRM5	unknown	Ki 6.41
Glutamate receptor ionotropic, kainate 3	Grik3	unknown	Ki 6.31
Adenosine receptor A3	ADORA3	unknown	IC50 6.21
Glutamate receptor ionotropic, kainate 5	GRIK5	unknown	Ki 6.15
Glutamate receptor ionotropic, kainate 1	GRIK1	unknown	Ki 6.15
Glutamate receptor ionotropic, kainate 3	GRIK3	unknown	Ki 6.10
Glutamate receptor 4	GRIA4	unknown	Ki 6.06
Glutamate receptor 2	GRIA2	unknown	Ki 6.03
Glutamate receptor ionotropic, kainate 2	GRIK2	unknown	Ki 5.96
Metabotropic glutamate receptor 7	GRM7	unknown	EC50 5.93
Glutamate receptor 1	GRIA1	unknown	Ki 5.87

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
A09AB01	ALIMENTARY TRACT AND METABOLISM › DIGESTIVES, INCL. ENZYMES › DIGESTIVES, INCL. ENZYMES › Acid preparations

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Toxic epidermal necrolysis	70.5
Foetal growth restriction	62.3
Compartment syndrome	60.4
Vasoplegia syndrome	48.8

Chemical structure

• Molecular formula: C₅H₉NO₄
• Molecular weight: 147.13 g/mol
• CAS number: 56-86-0
• InChIKey: WHUUTDBJXJRKMK-VKHMYHEASA-N
• PubChem CID: 33032

N[C@@H](CCC(O)=O)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Glutamic acid work?

Its molecular targets in DrugCentral include GRIK4, Grm8, GRM3 (agonist) and SLC1A1.

What is the chemical formula of Glutamic acid?

Glutamic acid has the molecular formula C5H9NO4 and a molecular weight of 147.13 g/mol.

Sources

• DrugCentral drug card 1310 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1255943 — compound record and bioactivity
• PubChem CID 33032 — chemical identifiers
• DrugBank DB00142 — drug record
• FDA UNII 3KX376GY7L — substance identity
• DailyMed: FDA labels for Glutamic acid — current prescribing information (label search)
• UniProt Q16099 (GRIK4) — target protein
• UniProt Q14832 (GRM3) — target protein
• UniProt P43005 (SLC1A1) — target protein
• UniProt Q13255 (GRM1) — target protein
• UniProt P42263 (GRIA3) — target protein
• UniProt Q14416 (GRM2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

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