About Excitatory amino acid transporter 3
Excitatory amino acid transporter 3 (SLC1A1) is a protein
from Homo sapiens identified by UniProt accession
P43005, 524 residues long.
MolForge cross-references it against 0 known binders and
190 disease associations.
Target properties
| Protein name | Excitatory amino acid transporter 3 |
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| UniProt accession | P43005 |
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| Gene | SLC1A1 |
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| Organism | Homo sapiens |
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| Length | 524 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
|---|
| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (190)
Diseases linked to this target (Open Targets).
- dicarboxylic aminoaciduria · score 0.64
- schizophrenia · score 0.46
- mean platelet volume · score 0.38
- Sensorineural hearing impairment · score 0.37
- response to risperidone · score 0.33
- neurodegenerative disease · score 0.27
- Rare genetic intellectual disability with developmental anomaly · score 0.27
- response to antipsychotic drug · score 0.26
- platelet crit · score 0.18
- obsessive-compulsive disorder · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43005-F1 | alphafold | PREDICTED | 80.15 | — |
Amino-acid sequence (524 residues)
MGKPARKGCE WKRFLKNNWV LLSTVAAVVL GITTGVLVRE HSNLSTLEKF YFAFPGEILM RMLKLIILPL IISSMITGVA ALDSNVSGKI GLRAVVYYFC TTLIAVILGI VLVVSIKPGV TQKVGEIART GSTPEVSTVD AMLDLIRNMF PENLVQACFQ QYKTKREEVK PPSDPEMNMT EESFTAVMTT AISKNKTKEY KIVGMYSDGI NVLGLIVFCL VFGLVIGKMG EKGQILVDFF NALSDATMKI VQIIMCYMPL GILFLIAGKI IEVEDWEIFR KLGLYMATVL TGLAIHSIVI LPLIYFIVVR KNPFRFAMGM AQALLTALMI SSSSATLPVT FRCAEENNQV DKRITRFVLP VGATINMDGT ALYEAVAAVF IAQLNDLDLG IGQIITISIT ATSASIGAAG VPQAGLVTMV IVLSAVGLPA EDVTLIIAVD WLLDRFRTMV NVLGDAFGTG IVEKLSKKEL EQMDVSSEVN IVNPFALEST ILDNEDSDTK KSYVNGGFAV DKSDTISFTQ TSQF
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