About Glutathione reductase, mitochondrial
Glutathione reductase, mitochondrial (GSR) is a protein
from Homo sapiens identified by UniProt accession
P00390, 522 residues long.
MolForge cross-references it against 0 known binders and
489 disease associations.
Target properties
| Protein name | Glutathione reductase, mitochondrial |
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| UniProt accession | P00390 |
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| Gene | GSR |
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| Organism | Homo sapiens |
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| Length | 522 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (489)
Diseases linked to this target (Open Targets).
- hemolytic anemia due to glutathione reductase deficiency · score 0.66
- glioblastoma multiforme · score 0.55
- multiple myeloma · score 0.54
- neurodegenerative disease · score 0.49
- Hodgkins lymphoma · score 0.48
- medulloblastoma · score 0.46
- astrocytoma · score 0.46
- glioma · score 0.46
- neoplasm · score 0.45
- lymphoma · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P00390-F1 | alphafold | PREDICTED | 91.62 | — |
Amino-acid sequence (522 residues)
MALLPRALSA GAGPSWRRAA RAFRGFLLLL PEPAALTRAL SRAMACRQEP QPQGPPPAAG AVASYDYLVI GGGSGGLASA RRAAELGARA AVVESHKLGG TCVNVGCVPK KVMWNTAVHS EFMHDHADYG FPSCEGKFNW RVIKEKRDAY VSRLNAIYQN NLTKSHIEII RGHAAFTSDP KPTIEVSGKK YTAPHILIAT GGMPSTPHES QIPGASLGIT SDGFFQLEEL PGRSVIVGAG YIAVEMAGIL SALGSKTSLM IRHDKVLRSF DSMISTNCTE ELENAGVEVL KFSQVKEVKK TLSGLEVSMV TAVPGRLPVM TMIPDVDCLL WAIGRVPNTK DLSLNKLGIQ TDDKGHIIVD EFQNTNVKGI YAVGDVCGKA LLTPVAIAAG RKLAHRLFEY KEDSKLDYNN IPTVVFSHPP IGTVGLTEDE AIHKYGIENV KTYSTSFTPM YHAVTKRKTK CVMKMVCANK EEKVVGIHMQ GLGCDEMLQG FAVAVKMGAT KADFDNTVAI HPTSSEELVT LR
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