Immunoglobulin heavy constant gamma 4 (IGHG4)

About Immunoglobulin heavy constant gamma 4

Immunoglobulin heavy constant gamma 4 (IGHG4) is a protein from Homo sapiens identified by UniProt accession P01861, 396 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.

Target properties

Protein name	Immunoglobulin heavy constant gamma 4
UniProt accession	P01861
Gene	IGHG4
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (150)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
immune deficiency, familial variable · score 0.08
Barrett's esophagus · score 0.08
common variable immunodeficiency · score 0.08
combined immunodeficiency with skin granulomas · score 0.07
hyper-IgM syndrome type 3 · score 0.07
classic Hodgkin lymphoma · score 0.07
Hodgkins lymphoma · score 0.07
inborn error of immunity · score 0.07
severe combined immunodeficiency due to CARD11 deficiency · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P01861-F1	alphafold	PREDICTED	86.78	—

Amino-acid sequence (396 residues)

ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS GLYSLSSVVT VPSSSLGTKT YTCNVDHKPS NTKVDKRVES KYGPPCPSCP APEFLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG NVFSCSVMHE ALHNHYTQKS LSLSLELQLE ESCAEAQDGE LDGLWTTITI FITLFLLSVC YSATVTFFKV KWIFSSVVDL KQTIVPDYRN MIRQGA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards