About Troponin C, skeletal muscle
Troponin C, skeletal muscle (TNNC2) is a protein
from Homo sapiens identified by UniProt accession
P02585, 160 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | Troponin C, skeletal muscle |
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| UniProt accession | P02585 |
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| Gene | TNNC2 |
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| Organism | Homo sapiens |
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| Length | 160 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (42)
Diseases linked to this target (Open Targets).
- amyotrophic lateral sclerosis · score 0.34
- neurodegenerative disease · score 0.23
- breast adenocarcinoma · score 0.23
- glioblastoma multiforme · score 0.16
- endometrial cancer · score 0.13
- head and neck squamous cell carcinoma · score 0.07
- chronic obstructive pulmonary disease · score 0.07
- intermittent vascular claudication · score 0.07
- Myasthenia gravis · score 0.07
- peripheral arterial disease · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P02585-F1 | alphafold | PREDICTED | 84.01 | — |
Amino-acid sequence (160 residues)
MTDQQAEARS YLSEEMIAEF KAAFDMFDAD GGGDISVKEL GTVMRMLGQT PTKEELDAII EEVDEDGSGT IDFEEFLVMM VRQMKEDAKG KSEEELAECF RIFDRNADGY IDPEELAEIF RASGEHVTDE EIESLMKDGD KNNDGRIDFD EFLKMMEGVQ
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