About Apolipoprotein C-III
Apolipoprotein C-III (APOC3) is a protein
from Homo sapiens identified by UniProt accession
P02656, 99 residues long.
MolForge cross-references it against 0 known binders and
549 disease associations.
Target properties
| Protein name | Apolipoprotein C-III |
|---|
| UniProt accession | P02656 |
|---|
| Gene | APOC3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 99 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (549)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.65
- high density lipoprotein cholesterol measurement · score 0.63
- phospholipids:total lipids ratio · score 0.58
- apolipoprotein c-III deficiency · score 0.58
- Red cell distribution width · score 0.57
- cholesteryl ester measurement · score 0.57
- lipoprotein measurement · score 0.57
- apolipoprotein B measurement · score 0.55
- low density lipoprotein cholesterol measurement · score 0.55
- platelet component distribution width · score 0.53
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P02656-F1 | alphafold | PREDICTED | 67.57 | — |
Amino-acid sequence (99 residues)
MQPRVLLVVA LLALLASARA SEAEDASLLS FMQGYMKHAT KTAKDALSSV QESQVAQQAR GWVTDGFSSL KDYWSTVKDK FSEFWDLDPE VRPTSAVAA
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