Olezarsen
Antisense Oligonucleotide
Also known as: akcea-apociii-lrx, ION-678354, ISIS 678354, olezarsen sodium, tryngolza
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Olezarsen is a drug in the Antisense Oligonucleotide class catalogued in DrugCentral. It was first approved by the FDA in 2024. DrugCentral lists 1 molecular target, including APOC3. Recorded indications include Familial chylomicronemia syndrome.
- Drug class: Antisense Oligonucleotide; APOC-III-directed RNA Interaction.
- Molecular targets: APOC3 (1 listed in DrugCentral).
- Indications: Familial chylomicronemia syndrome.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (1)
- Familial chylomicronemia syndrome
Mechanism & targets
| Established pharmacologic class | Antisense Oligonucleotide; APOC-III-directed RNA Interaction |
|---|
Molecular targets (1)
| Target | Gene | Action | Activity |
|---|---|---|---|
| apolipoprotein C-III (apoC-III) mRNA | APOC3 | other | IC50 6.74 |
Regulatory approvals (2)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 2025-09-17 | EMA | — | Swedish Orphan Biovitrum AB | Yes |
| 2024-12-19 | FDA | — | Ionis Pharmaceuticals | Yes |
Pharmacogenomics
Drug-label and guideline annotations from PharmGKB and CPIC.
- EMA label: LPL
- FDA label: LPL
Chemical structure
| Molecular formula | — |
|---|---|
| Molecular weight | — |
| CAS number | — |
| InChIKey | — |
| PubChem CID | — |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Olezarsen used for?
DrugCentral lists the following indications for Olezarsen: Familial chylomicronemia syndrome.
How does Olezarsen work?
Its molecular targets in DrugCentral include APOC3.
When was Olezarsen first approved?
Olezarsen was first approved by the FDA in 2024.
What drug class does Olezarsen belong to?
Olezarsen is in the Antisense Oligonucleotide class.
Browse: all drugs starting with O · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 5846 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL4650263 — compound record and bioactivity
- FDA UNII S3RS2SA30L — substance identity
- DailyMed: FDA labels for Olezarsen — current prescribing information (label search)
- UniProt P02656 (APOC3) — target protein
- PharmGKB / CPIC — pharmacogenomic label annotations
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.