Phospholipase A2 (PLA2G1B)

About Phospholipase A2

Phospholipase A2 (PLA2G1B) is a protein from Homo sapiens identified by UniProt accession P04054, 148 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.

Target properties

Protein name	Phospholipase A2
UniProt accession	P04054
Gene	PLA2G1B
Organism	Homo sapiens
Length	148 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (108)

Diseases linked to this target (Open Targets).

neuroinflammatory disorder · score 0.22
neurodegenerative disease · score 0.21
antisocial behaviour measurement · score 0.19
attention deficit hyperactivity disorder · score 0.19
substance abuse · score 0.19
rheumatoid arthritis · score 0.11
appendicular lean mass · score 0.11
diastolic blood pressure · score 0.10
systolic blood pressure · score 0.10
cutaneous melanoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04054-F1	alphafold	PREDICTED	88.48	—

Amino-acid sequence (148 residues)

MKLLVLAVLL TVAAADSGIS PRAVWQFRKM IKCVIPGSDP FLEYNNYGCY CGLGGSGTPV DELDKCCQTH DNCYDQAKKL DSCKFLLDNP YTHTYSYSCS GSAITCSSKN KECEAFICNC DRNAAICFSK APYNKAHKNL DTKKYCQS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards