About Lysosomal acid glucosylceramidase
Lysosomal acid glucosylceramidase (GBA1) is a protein
from Homo sapiens identified by UniProt accession
P04062, 536 residues long.
MolForge cross-references it against 0 known binders and
575 disease associations.
Target properties
| Protein name | Lysosomal acid glucosylceramidase |
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| UniProt accession | P04062 |
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| Gene | GBA1 |
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| Organism | Homo sapiens |
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| Length | 536 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (575)
Diseases linked to this target (Open Targets).
- Gaucher disease type 1 · score 0.82
- Gaucher disease type 2 · score 0.80
- Gaucher disease type I · score 0.80
- Gaucher disease perinatal lethal · score 0.79
- Gaucher disease type 3 · score 0.79
- Gaucher disease type II · score 0.78
- Gaucher disease type III · score 0.77
- Parkinson disease · score 0.73
- Gaucher disease-ophthalmoplegia-cardiovascular calcification syndrome · score 0.71
- Gaucher disease · score 0.69
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P04062-F1 | alphafold | PREDICTED | 93.24 | — |
Amino-acid sequence (536 residues)
MEFSSPSREE CPKPLSRVSI MAGSLTGLLL LQAVSWASGA RPCIPKSFGY SSVVCVCNAT YCDSFDPPTF PALGTFSRYE STRSGRRMEL SMGPIQANHT GTGLLLTLQP EQKFQKVKGF GGAMTDAAAL NILALSPPAQ NLLLKSYFSE EGIGYNIIRV PMASCDFSIR TYTYADTPDD FQLHNFSLPE EDTKLKIPLI HRALQLAQRP VSLLASPWTS PTWLKTNGAV NGKGSLKGQP GDIYHQTWAR YFVKFLDAYA EHKLQFWAVT AENEPSAGLL SGYPFQCLGF TPEHQRDFIA RDLGPTLANS THHNVRLLML DDQRLLLPHW AKVVLTDPEA AKYVHGIAVH WYLDFLAPAK ATLGETHRLF PNTMLFASEA CVGSKFWEQS VRLGSWDRGM QYSHSIITNL LYHVVGWTDW NLALNPEGGP NWVRNFVDSP IIVDITKDTF YKQPMFYHLG HFSKFIPEGS QRVGLVASQK NDLDAVALMH PDGSAVVVVL NRSSKDVPLT IKDPAVGFLE TISPGYSIHT YLWRRQ
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