About Glyceraldehyde-3-phosphate dehydrogenase
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a protein
from Homo sapiens identified by UniProt accession
P04406, 335 residues long.
MolForge cross-references it against 0 known binders and
737 disease associations.
Target properties
| Protein name | Glyceraldehyde-3-phosphate dehydrogenase |
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| UniProt accession | P04406 |
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| Gene | GAPDH |
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| Organism | Homo sapiens |
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| Length | 335 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (737)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- neuroinflammatory disorder · score 0.25
- erythrocyte count · score 0.17
- endometrial cancer · score 0.12
- neoplasm · score 0.11
- glycogen storage disease due to lactate dehydrogenase H-subunit deficiency · score 0.11
- Sepsis · score 0.11
- cancer · score 0.10
- hepatocellular carcinoma · score 0.09
- Huntington disease · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P04406-F1 | alphafold | PREDICTED | 98.12 | — |
Amino-acid sequence (335 residues)
MGKVKVGVNG FGRIGRLVTR AAFNSGKVDI VAINDPFIDL NYMVYMFQYD STHGKFHGTV KAENGKLVIN GNPITIFQER DPSKIKWGDA GAEYVVESTG VFTTMEKAGA HLQGGAKRVI ISAPSADAPM FVMGVNHEKY DNSLKIISNA SCTTNCLAPL AKVIHDNFGI VEGLMTTVHA ITATQKTVDG PSGKLWRDGR GALQNIIPAS TGAAKAVGKV IPELNGKLTG MAFRVPTANV SVVDLTCRLE KPAKYDDIKK VVKQASEGPL KGILGYTEHQ VVSSDFNSDT HSSTFDAGAG IALNDHFVKL ISWYDNEFGY SNRVVDLMAH MASKE
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