About Alkaline phosphatase, tissue-nonspecific isozyme
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL) is a protein
from Homo sapiens identified by UniProt accession
P05186, 524 residues long.
MolForge cross-references it against 0 known binders and
473 disease associations.
Target properties
| Protein name | Alkaline phosphatase, tissue-nonspecific isozyme |
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| UniProt accession | P05186 |
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| Gene | ALPL |
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| Organism | Homo sapiens |
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| Length | 524 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (7)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (473)
Diseases linked to this target (Open Targets).
- adult hypophosphatasia · score 0.86
- infantile hypophosphatasia · score 0.83
- hypophosphatasia · score 0.79
- alkaline phosphatase measurement · score 0.72
- odontohypophosphatasia · score 0.68
- phosphate measurement · score 0.59
- Skeletal dysplasia · score 0.57
- calcium measurement · score 0.54
- osteogenesis imperfecta · score 0.53
- genetic disorder · score 0.52
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05186-F1 | alphafold | PREDICTED | 93.29 | — |
Amino-acid sequence (524 residues)
MISPFLVLAI GTCLTNSLVP EKEKDPKYWR DQAQETLKYA LELQKLNTNV AKNVIMFLGD GMGVSTVTAA RILKGQLHHN PGEETRLEMD KFPFVALSKT YNTNAQVPDS AGTATAYLCG VKANEGTVGV SAATERSRCN TTQGNEVTSI LRWAKDAGKS VGIVTTTRVN HATPSAAYAH SADRDWYSDN EMPPEALSQG CKDIAYQLMH NIRDIDVIMG GGRKYMYPKN KTDVEYESDE KARGTRLDGL DLVDTWKSFK PRYKHSHFIW NRTELLTLDP HNVDYLLGLF EPGDMQYELN RNNVTDPSLS EMVVVAIQIL RKNPKGFFLL VEGGRIDHGH HEGKAKQALH EAVEMDRAIG QAGSLTSSED TLTVVTADHS HVFTFGGYTP RGNSIFGLAP MLSDTDKKPF TAILYGNGPG YKVVGGEREN VSMVDYAHNN YQAQSAVPLR HETHGGEDVA VFSKGPMAHL LHGVHEQNYV PHVMAYAACI GANLGHCAPA SSAGSLAAGP LLLALALYPL SVLF
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