Bufylline

RESPIRATORY SYSTEM

Key facts

Bufylline is a drug catalogued in DrugCentral. DrugCentral lists 20 molecular targets, including ADORA2A, ADORA1 and ADORA3.

• Molecular targets: ADORA2A, ADORA1, ADORA3 and Adora1 (20 listed in DrugCentral).
• ATC code: R03DA10 (Xanthines).

Mechanism & targets

Molecular targets (20)

Target	Gene	Action	Activity
Adenosine receptor A2a	ADORA2A	antagonist	Ki 9.22
Adenosine receptor A1	ADORA1	antagonist	Ki 9.22
Adenosine receptor A3	ADORA3	antagonist	Ki 7.85
Adenosine receptor A1	Adora1	unknown	Ki 6.15
Adenosine A2 receptor	Adora2b|Adora2a	unknown	Ki 5.88
Adenosine receptor A2b	ADORA2B	antagonist	Ki 5.57
Adenosine receptor A1	ADORA1	unknown	Ki 5.42
Adenosine receptor A2a	Adora2a	unknown	Ki 5.17
Adenosine receptor A1	ADORA1	unknown	Ki 5.01
Adenosine A2a receptor	ADORA2A	unknown	Ki 4.89
Adenosine A2 receptor	ADORA2A|ADORA2B	antagonist	Ki 4.85
Adenosine A2b receptor	Adora2b	unknown	Ki 4.82
Adenosine receptor	Adora1|Adora3|Adora2b|Adora2a	unknown	Ki 4.70
Phosphodiesterase 4	PDE4A|PDE4B|PDE4C|PDE4D	inhibitor	Ki 4.25
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	PIK3CD	unknown	IC50 4.12
Uncharacterized protein	PDE3B	unknown	Ki 4.11
Alkaline phosphatase, tissue-nonspecific isozyme	ALPL	unknown	Ki 4.09
Adenosine receptor A3	Adora3	unknown	Ki 4.07
Heart phosphodiesterase	PDE3B|PDE1A|PDE1B	unknown	IC50 4.04
Phosphodiesterase 3	PDE3B|PDE3A	inhibitor	—

ATC classification

ATC code	Therapeutic hierarchy
R03DA10	RESPIRATORY SYSTEM › DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES › OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES › Xanthines

Chemical structure

• Molecular formula: —
• Molecular weight: —
• CAS number: —
• InChIKey: —
• PubChem CID: 21850

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Bufylline work?

Its molecular targets in DrugCentral include ADORA2A (antagonist), ADORA1 (antagonist), ADORA3 (antagonist) and Adora1.

Sources

• DrugCentral drug card 4426 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2104089 — compound record and bioactivity
• PubChem CID 21850 — chemical identifiers
• DrugBank DB13812 — drug record
• FDA UNII VOU5V0B772 — substance identity
• UniProt P29274 (ADORA2A) — target protein
• UniProt P30542 (ADORA1) — target protein
• UniProt P0DMS8 (ADORA3) — target protein
• UniProt P29275 (ADORA2B) — target protein
• UniProt O00329 (PIK3CD) — target protein
• UniProt P05186 (ALPL) — target protein

How this page is built: methodology · editorial policy & corrections.