Diprophylline
RESPIRATORY SYSTEM
Also known as: aristophyllin, corphyllin, diphyllin, diphylline, diprophyllin, dyphylline, glyphyllin, glyphylline, hidroxiteofillina, neophyllin, neutrafillina, neutraphyllin
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Diprophylline is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1951. DrugCentral lists 2 molecular targets, including PDE3A and PDE4B. Recorded indications include Asthma, Asthma management, Asthma night-time symptoms and Asthma-chronic obstructive pulmonary disease overlap syndrome.
- Approval status: ofm (first approved 1951 by the FDA).
- Molecular targets: PDE3A and PDE4B (2 listed in DrugCentral).
- Indications: Asthma, Asthma management, Asthma night-time symptoms, Asthma-chronic obstructive pulmonary disease overlap syndrome and Bronchospasm and others.
- ATC code: R03DA01 (Xanthines).
- Molecular formula: C10H14N4O4; molecular weight 254.25 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (7)
- Asthma
- Asthma management
- Asthma night-time symptoms
- Asthma-chronic obstructive pulmonary disease overlap syndrome
- Bronchospasm
- Chronic bronchitis
- Pulmonary emphysema
Off-label uses (2)
- Chronic Obstructive Pulmonary Disease with Bronchospasms
- COPD Associated with Chronic Bronchitis
Contraindications (39)
- Alcoholism
- Anemia
- Angina pectoris
- Angle-closure glaucoma
- Benign prostatic hyperplasia
- Breastfeeding (mother)
- Chronic heart failure
- Chronic myocardial ischemia
- Conduction disorder of the heart
- Cor pulmonale
- Depressive disorder
- Diabetes mellitus
- Disease of liver
- Disorder of cardiovascular system
- Disorder of coronary artery
- Dyspnea
- Gastritis
- Glaucoma
- Heart disease
- Hepatic coma
- Hepatic encephalopathy
- Hepatic failure
- Hyperammonemia
- Hypertensive disorder
- Hyperthyroidism
- Kidney disease
- Myocardial infarction
- Myocardial ischemia
- Neutropenic disorder
- Peptic ulcer
- + 9 more
Mechanism & targets
Molecular targets (2)
| Target | Gene | Action | Activity |
|---|---|---|---|
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A | PDE3A | inhibitor | — |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | PDE4B | inhibitor | — |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1951-03-07 | FDA | — | — |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
R03DA01 | RESPIRATORY SYSTEM › DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES › OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES › Xanthines |
R03DA51 | RESPIRATORY SYSTEM › DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES › OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES › Xanthines |
R03DB01 | RESPIRATORY SYSTEM › DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES › OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES › Xanthines and adrenergics |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Diprophylline is on its molecule page.
| Molecular formula | C10H14N4O4 |
|---|---|
| Molecular weight | 254.25 g/mol |
| CAS number | 479-18-5 |
| InChIKey | KSCFJBIXMNOVSH-UHFFFAOYSA-N |
| PubChem CID | 3182 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Diprophylline used for?
DrugCentral lists the following indications for Diprophylline: Asthma, Asthma management, Asthma night-time symptoms, Asthma-chronic obstructive pulmonary disease overlap syndrome, Bronchospasm, Chronic bronchitis and Pulmonary emphysema.
How does Diprophylline work?
Its molecular targets in DrugCentral include PDE3A (inhibitor) and PDE4B (inhibitor).
When was Diprophylline first approved?
Diprophylline was first approved by the FDA in 1951.
What is the chemical formula of Diprophylline?
Diprophylline has the molecular formula C10H14N4O4 and a molecular weight of 254.25 g/mol.
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Sources
- DrugCentral drug card 976 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL1752 — compound record and bioactivity
- PubChem CID 3182 — chemical identifiers
- DrugBank DB00651 — drug record
- FDA UNII 263T0E9RR9 — substance identity
- DailyMed: FDA labels for Diprophylline — current prescribing information (label search)
- UniProt Q14432 (PDE3A) — target protein
- UniProt Q07343 (PDE4B) — target protein
How this page is built: methodology · editorial policy & corrections.
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