About 3',5'-cyclic-AMP phosphodiesterase 4B
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) is a protein
from Homo sapiens identified by UniProt accession
Q07343, 736 residues long.
MolForge cross-references it against 0 known binders and
444 disease associations.
Target properties
| Protein name | 3',5'-cyclic-AMP phosphodiesterase 4B |
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| UniProt accession | Q07343 |
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| Gene | PDE4B |
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| Organism | Homo sapiens |
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| Length | 736 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (11)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (444)
Diseases linked to this target (Open Targets).
- asthma · score 0.60
- chronic obstructive pulmonary disease · score 0.60
- psoriasis · score 0.60
- Headache · score 0.60
- atopic eczema · score 0.58
- Airway obstruction · score 0.58
- psoriatic arthritis · score 0.57
- ulcerative colitis · score 0.56
- coronary artery disease · score 0.55
- stroke · score 0.55
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q07343-F1 | alphafold | PREDICTED | 70.39 | — |
Amino-acid sequence (736 residues)
MKKSRSVMTV MADDNVKDYF ECSLSKSYSS SSNTLGIDLW RGRRCCSGNL QLPPLSQRQS ERARTPEGDG ISRPTTLPLT TLPSIAITTV SQECFDVENG PSPGRSPLDP QASSSAGLVL HATFPGHSQR RESFLYRSDS DYDLSPKAMS RNSSLPSEQH GDDLIVTPFA QVLASLRSVR NNFTILTNLH GTSNKRSPAA SQPPVSRVNP QEESYQKLAM ETLEELDWCL DQLETIQTYR SVSEMASNKF KRMLNRELTH LSEMSRSGNQ VSEYISNTFL DKQNDVEIPS PTQKDREKKK KQQLMTQISG VKKLMHSSSL NNTSISRFGV NTENEDHLAK ELEDLNKWGL NIFNVAGYSH NRPLTCIMYA IFQERDLLKT FRISSDTFIT YMMTLEDHYH SDVAYHNSLH AADVAQSTHV LLSTPALDAV FTDLEILAAI FAAAIHDVDH PGVSNQFLIN TNSELALMYN DESVLENHHL AVGFKLLQEE HCDIFMNLTK KQRQTLRKMV IDMVLATDMS KHMSLLADLK TMVETKKVTS SGVLLLDNYT DRIQVLRNMV HCADLSNPTK SLELYRQWTD RIMEEFFQQG DKERERGMEI SPMCDKHTAS VEKSQVGFID YIVHPLWETW ADLVQPDAQD ILDTLEDNRN WYQSMIPQSP SPPLDEQNRD CQGLMEKFQF ELTLDEEDSE GPEKEGEGHS YFSSTKTLCV IDPENRDSLG ETDIDIATED KSPVDT
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