Difamilast

Drug profile

Key facts

Difamilast is an onp drug catalogued in DrugCentral. It was first approved by the PMDA in 2021. DrugCentral lists 1 molecular target, including PDE4B. Recorded indications include Atopic dermatitis.

• Approval status: onp (first approved 2021 by the PMDA).
• Molecular targets: PDE4B (1 listed in DrugCentral).
• Indications: Atopic dermatitis.
• Molecular formula: C23H24F2N2O5; molecular weight 446.45 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Atopic dermatitis

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	inhibitor	IC50 7.95

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2021-09-27	PMDA	—	OTSUKA PHARMACEUTICAL Co., Ltd

Chemical structure

• Molecular formula: C₂₃H₂₄F₂N₂O₅
• Molecular weight: 446.45 g/mol
• CAS number: 937782-05-3
• InChIKey: VFBILHPIHUPBPZ-UHFFFAOYSA-N
• PubChem CID: 57855696

CCOC1=C(C=CC=C1)C(=O)NCC1=COC(=N1)C1=CC(OC(C)C)=C(OC(F)F)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Difamilast used for?

DrugCentral lists the following indications for Difamilast: Atopic dermatitis.

How does Difamilast work?

Its molecular targets in DrugCentral include PDE4B (inhibitor).

When was Difamilast first approved?

Difamilast was first approved by the PMDA in 2021.

What is the chemical formula of Difamilast?

Difamilast has the molecular formula C23H24F2N2O5 and a molecular weight of 446.45 g/mol.

Sources

• DrugCentral drug card 5503 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL3989968 — compound record and bioactivity
• PubChem CID 57855696 — chemical identifiers
• DrugBank DB14987 — drug record
• FDA UNII T3U32GLJ0F — substance identity
• UniProt Q07343 (PDE4B) — target protein

How this page is built: methodology · editorial policy & corrections.