Adenosine receptor A2b (ADORA2B)

About Adenosine receptor A2b

Adenosine receptor A2b (ADORA2B) is a protein from Homo sapiens identified by UniProt accession P29275, 332 residues long. MolForge cross-references it against 0 known binders and 392 disease associations.

Target properties

Protein name	Adenosine receptor A2b
UniProt accession	P29275
Gene	ADORA2B
Organism	Homo sapiens
Length	332 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (11)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (392)

Diseases linked to this target (Open Targets).

migraine disorder · score 0.61
asthma · score 0.60
paroxysmal tachycardia · score 0.59
Apnea · score 0.58
Wolff-Parkinson-White Syndrome · score 0.57
pain · score 0.57
Airway obstruction · score 0.57
Headache · score 0.55
chronic obstructive pulmonary disease · score 0.54
chronic kidney disease · score 0.54

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P29275-F1	alphafold	PREDICTED	88.10	—

Amino-acid sequence (332 residues)

MLLETQDALY VALELVIAAL SVAGNVLVCA AVGTANTLQT PTNYFLVSLA AADVAVGLFA IPFAITISLG FCTDFYGCLF LACFVLVLTQ SSIFSLLAVA VDRYLAICVP LRYKSLVTGT RARGVIAVLW VLAFGIGLTP FLGWNSKDSA TNNCTEPWDG TTNESCCLVK CLFENVVPMS YMVYFNFFGC VLPPLLIMLV IYIKIFLVAC RQLQRTELMD HSRTTLQREI HAAKSLAMIV GIFALCWLPV HAVNCVTLFQ PAQGKNKPKW AMNMAILLSH ANSVVNPIVY AYRNRDFRYT FHKIISRYLL CQADVKSGNG QAGVQPALGV GL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards