Adenosine receptor A1 (ADORA1)

About Adenosine receptor A1

Adenosine receptor A1 (ADORA1) is a protein from Homo sapiens identified by UniProt accession P30542, 326 residues long. MolForge cross-references it against 0 known binders and 385 disease associations.

Target properties

Protein name	Adenosine receptor A1
UniProt accession	P30542
Gene	ADORA1
Organism	Homo sapiens
Length	326 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (385)

Diseases linked to this target (Open Targets).

asthma · score 0.70
migraine disorder · score 0.61
paroxysmal tachycardia · score 0.59
Apnea · score 0.58
pain · score 0.57
Airway obstruction · score 0.57
chronic obstructive pulmonary disease · score 0.57
Wolff-Parkinson-White Syndrome · score 0.56
Headache · score 0.55
Acute kidney injury · score 0.52

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P30542-F1	alphafold	PREDICTED	92.45	—

Amino-acid sequence (326 residues)

MPPSISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA IAVDRYLRVK IPLRYKMVVT PRRAAVAIAG CWILSFVVGL TPMFGWNNLS AVERAWAANG SMGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL HILNCITLFC PSCHKPSILT YIAIFLTHGN SAMNPIVYAF RIQKFRVTFL KIWNDHFRCQ PAPPIDEDLP EERPDD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards